一項(xiàng)研究表明,，已被證明能夠影響消化和免疫健康的個(gè)人獨(dú)特的細(xì)菌組成可能受到出生時(shí)刻的影響。
Maria Dominguez-Bello及其同事對(duì)來(lái)自9位母親和10位出生后不足一天的新生兒進(jìn)行了細(xì)菌取樣。這組科學(xué)家發(fā)現(xiàn),，陰道分娩的嬰兒獲得的細(xì)菌群落類(lèi)似于他們的母親的陰道細(xì)菌組成,，而通過(guò)剖宮產(chǎn)出生的嬰兒攜帶了常見(jiàn)的皮膚細(xì)菌，這些細(xì)菌并不比來(lái)自其他剖宮產(chǎn)嬰兒的細(xì)菌更加類(lèi)似于他們的母親的細(xì)菌組成,。
通常與乳汁消化,、細(xì)菌病或陰道感染有關(guān)的細(xì)菌占了來(lái)自陰道分娩的兒童的皮膚和嘴的樣本的大部分。剖宮產(chǎn)嬰兒的細(xì)菌群落大部分是由與食物中毒,、白喉和痤瘡有關(guān)的細(xì)菌組成的,。此前的研究表明，通過(guò)剖宮產(chǎn)出生的嬰兒可能比陰道分娩的嬰兒對(duì)某些病原體,、過(guò)敏和哮喘更加敏感,。這組作者說(shuō)，在分娩過(guò)程中母親陰道的細(xì)菌直接傳給她的嬰兒可能通過(guò)限制更有害的病原體的定植從而有助于讓嬰兒抵御有害疾病,。(生物谷Bioon.net)
生物谷推薦原文出處：
PNAS doi: 10.1073/pnas.1002601107
Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
Maria G. Dominguez-Belloa,1,2, Elizabeth K. Costellob,1,3, Monica Contrerasc, Magda Magrisd, Glida Hidalgod, Noah Fierere,f, and Rob Knightb,g
aDepartment of Biology, University of Puerto Rico, San Juan, Puerto Rico 00931;
bDepartment of Chemistry and Biochemistry,
eDepartment of Ecology and Evolutionary Biology, and
fCooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80305;
cCenter of Biophysics and Biochemistry, Venezuelan Institute for Scientific Research, Caracas 1020A, Venezuela;
d Amazonic Center for Research and Control of Tropical Diseases, Puerto Ayacucho 7101, Amazonas, Venezuela; and
gThe Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80305
Upon delivery, the neonate is exposed for the first time to a wide array of microbes from a variety of sources, including maternal bacteria. Although prior studies have suggested that delivery mode shapes the microbiota's establishment and, subsequently, its role in child health, most researchers have focused on specific bacterial taxa or on a single body habitat, the gut. Thus, the initiation stage of human microbiome development remains obscure. The goal of the present study was to obtain a community-wide perspective on the influence of delivery mode and body habitat on the neonate's first microbiota. We used multiplexed 16S rRNA gene pyrosequencing to characterize bacterial communities from mothers and their newborn babies, four born vaginally and six born via Cesarean section. Mothers’ skin, oral mucosa, and vagina were sampled 1 h before delivery, and neonates’ skin, oral mucosa, and nasopharyngeal aspirate were sampled <5 min, and meconium <24 h, after delivery. We found that in direct contrast to the highly differentiated communities of their mothers, neonates harbored bacterial communities that were undifferentiated across multiple body habitats, regardless of delivery mode. Our results also show that vaginally delivered infants acquired bacterial communities resembling their own mother's vaginal microbiota, dominated by Lactobacillus, Prevotella, or Sneathia spp., and C-section infants harbored bacterial communities similar to those found on the skin surface, dominated by Staphylococcus, Corynebacterium, and Propionibacterium spp. These findings establish an important baseline for studies tracking the human microbiome's successional development in different body habitats following different delivery modes, and their associated effects on infant health.
