一項研究檢測了慢性疲勞綜合癥患者血細胞中的稱為鼠白血病病毒（MLV）相關病毒的一種病毒的遺傳特征,，該研究發(fā)表在《美國科學院學報》（PNAS）的網(wǎng)站上,。和該研究的論文一同發(fā)表的還有一篇關于這項研究的評論以及主編Randy Schekman談論《美國科學院學報》（PNAS）在評審,、接受和發(fā)表這篇論文所遵循的程序的一篇社論,。
以免疫和神經(jīng)病癥狀為特點的慢性疲勞綜合癥是一種病因未知的使人衰弱的疾病,。盡管微生物感染已經(jīng)被認為是引發(fā)它的因素,，迄今科學家尚未把任何一種原因與這種疾病明確地聯(lián)系在一起,。
Shyh-Ching Lo及其同事分析了從慢性疲勞綜合征患者的外周血單核細胞中提取的DNA,，結果在37位患者的32位中發(fā)現(xiàn)了鼠白血病病毒（MLV）樣病毒基因序列,。這組作者說，這些發(fā)現(xiàn)表明了需要進一步研究從而確定鼠白血病病毒（MLV）相關病毒是否在其他患者人群中發(fā)現(xiàn),，以及這些病毒是否起到了引發(fā)這種疾病的作用,。（生物谷Bioon.com）
生物谷推薦原文出處：
PNAS doi: 10.1073/pnas.1006901107
Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors
Shyh-Ching Lo a , 1 , Natalia Pripuzova a , Bingjie Li a , Anthony L. Komaroff b , Guo-Chiuan Hung a , Richard Wang c , and Harvey J. Alter c , 1
Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause. A recent study identified DNA from a xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101 patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy controls. However, four subsequent reports failed to detect any murine leukemia virus (MLV)-related virus gene sequences in blood of CFS patients. We examined 41 PBMC-derived DNA samples from 37 patients meeting accepted diagnostic criteria for CFS and found MLV-like virus gag gene sequences in 32 of 37 (86.5%) compared with only 3 of 44 (6.8%) healthy volunteer blood donors. No evidence of mouse DNA contamination was detected in the PCR assay system or the clinical samples. Seven of 8 gag-positive patients tested again positive in a sample obtained nearly 15 y later. In contrast to the reported findings of near-genetic identity of all XMRVs, we identified a genetically diverse group of MLV-related viruses. The gag and env sequences from CFS patients were more closely related to those of polytropic mouse endogenous retroviruses than to those of XMRVs and were even less closely related to those of ecotropic MLVs. Further studies are needed to determine whether the same strong association with MLV-related viruses is found in other groups of patients with CFS, whether these viruses play a causative role in the development of CFS, and whether they represent a threat to the blood supply.
