生物谷編者按：這是今天出版的《Science》刊登了華人科學家程長真（音譯）和李寧（音譯）采用miRNA來調(diào)節(jié)造血干細胞的分化，為傳統(tǒng)的干細胞分化開辟了新的方法和思路,。傳統(tǒng)的方法都是集中于使用細胞因子,，或?qū)ふ姨禺愋曰衔铮谶z傳學水平直接調(diào)控為干細胞定向分化提供了曙光,。但同時我們也應看到,，細胞的分化是多基因調(diào)控的，單一的基因調(diào)節(jié),，可能并不能達到理想的效果,，因此這篇研究屬于開創(chuàng)性研究，但更多的研究還要看后來者,。
MicroRNAs Modulate Hematopoietic Lineage Differentiation
Chang-Zheng Chen,1 Ling Li,1 Harvey F. Lodish,1,2* David P. Bartel1,2*
Science, Vol. 303, Issue 5654, 83-86, January 2, 2004
MicroRNAs (miRNAs) are an abundant class of 22-nucleotide regulatory RNAs found in plants and animals. Some miRNAs of plants, Caenorhabditis elegans, and Drosophila play important gene-regulatory roles during development by pairing to target mRNAs to specify posttranscriptional repression of these messages. We identify three miRNAs that are specifically expressed in hematopoietic cells and show that their expression is dynamically regulated during early hematopoiesis and lineage commitment. One of these miRNAs, miR-181, was preferentially expressed in the B-lymphoid cells of mouse bone marrow, and its ectopic expression in hematopoietic stem/progenitor cells led to an increased fraction of B-lineage cells in both tissue-culture differentiation assays and adult mice. Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development.
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