生物谷報(bào)道：剛剛出版的Nature以封面報(bào)道了剛剛發(fā)現(xiàn)在大腦內(nèi)存在一條獨(dú)特的星形膠質(zhì)細(xì)胞區(qū)域,，它內(nèi)含有大量的神經(jīng)干細(xì)胞，將神經(jīng)干細(xì)胞從側(cè)腦室源源不斷轉(zhuǎn)移至嗅球這一發(fā)現(xiàn),，不僅揭示了大腦內(nèi)神經(jīng)干細(xì)胞的大量來源,，同時(shí)也證明了神經(jīng)干細(xì)胞存在遷移現(xiàn)象。不過這些遷移的細(xì)胞的功能還不是很清楚,。
In adult rodents, one region of the brain, the subventricular zone, generates thousands of neurons every day. These cells migrate to the olfactory bulb to replace interneurons there. If the adult human brain contains a similarly productive region, there could be important implications for future developments in neuroregenerative therapy. A ribbon of astrocytes with stem cell potential has now been identified along the walls of the lateral ventricle of the adult human brain. The cover shows a reconstruction of the skull and brain, based on computed tomography, indicating regions of the subventricular zone where these stem cells are found. Unlike the stem cell progeny of the rodent brain, the young human neurons do not find their way to the olfactory bulb, so their precise function is not yet clear.
Original article:（Nature全文不免費(fèi)如果需要,，請(qǐng)向我們的管理員索取，寫信[email protected]）
Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
NADER SANAI, ANTHONY D. TRAMONTIN, ALFREDO QUIÑONES-HINOJOSA, NICHOLAS M. BARBARO, NALIN GUPTA, SANDEEP KUNWAR, MICHAEL T. LAWTON, MICHAEL W. MCDERMOTT, ANDREW T. PARSA, JOSÉ MANUEL-GARCÍA VERDUGO, MITCHEL S. BERGER & ARTURO ALVAREZ-BUYLLA
Nature 427, 740–744 (2004); doi:10.1038/nature02301
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Neuroscience: Immigration denied
PASKO RAKIC
The adult human brain cannot replace lost neurons. This might be because it is reluctant to accept newcomers into an already established neural network, rather than because potential progenitors are absent.
Nature 427, 685–686 (2004); doi:10.1038/427685a
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