生物谷報(bào)道：當(dāng)心臟病發(fā)作或中風(fēng)后,，醫(yī)師希望可以讓新血管快速地形成以加速傷口的愈合,。有一種實(shí)驗(yàn)性藥物可以動(dòng)員患者的血管新生細(xì)胞,，幫助患者的血管快速生成。
華盛頓大學(xué)醫(yī)學(xué)院的研究人員經(jīng)過(guò)多年研究證實(shí)了一種稱(chēng)為AMD3100的藥物可以在幾小時(shí)而非幾天的時(shí)間內(nèi),，從骨髓動(dòng)員患者的血管新生細(xì)胞,，AMD3100的作用類(lèi)似于G-CSF。它的作用機(jī)理是作為CXCR4的抑制劑發(fā)揮作用的,。
血管新生細(xì)胞主要位于骨髓中,，當(dāng)動(dòng)員時(shí)可以經(jīng)由血液循環(huán)來(lái)到受損的組織，并幫助修補(bǔ)和重新生長(zhǎng)可將氧氣和營(yíng)養(yǎng)物質(zhì)帶給受損組織的血管,。
G-CSF也可以將這些有利的細(xì)胞,，從骨髓帶入血液中，但是一直要等到第四天,，血管新生細(xì)胞才會(huì)進(jìn)入血液中,。在二項(xiàng)G-SCF的臨床試驗(yàn)中，都發(fā)現(xiàn)這種治療方式無(wú)法改進(jìn)心臟病發(fā)作的心肌補(bǔ)救效果,。
在本篇發(fā)表于Blood的文章中,，研究人員表示，AMD3100可以在四個(gè)小時(shí)內(nèi),，就能讓血液中某些血管新生細(xì)胞的數(shù)量增加10到20倍,，因此，這將是治療心臟病發(fā)作或中風(fēng)更有效的藥物,。
生物谷下面列出了有關(guān)該藥物的一系列研究論文,，感興趣的可以綜合閱讀。
原始出處:
Rebecca M Shepherd, Benjamin J Capoccia, Steven M Devine, John DiPersio, Kathryn M Trinkaus, David Ingram, and Daniel C Link
Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100
Blood, Aug 2006; doi:10.1182/blood-2006-06-030577 PDF
參閱文獻(xiàn)：
André Larochelle, Allen Krouse, Mark Metzger, Donald Orlic, Robert E. Donahue, Simon Fricker, Gary Bridger, Cynthia E. Dunbar, and Peiman Hematti
AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates
Blood, May 2006; 107: 3772 - 3778. PDF
Rebecca M Shepherd, Benjamin J Capoccia, Steven M Devine, John DiPersio, Kathryn M Trinkaus, David Ingram, and Daniel C Link
Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100
Blood, Aug 2006; doi:10.1182/blood-2006-06-030577 PDF
A. Larochelle, A. Krouse, M. Metzger, D. Orlic, R. E. Donahue, S. Fricker, G. Bridger, C. E. Dunbar, and P. Hematti
AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates
Blood, May 1, 2006; 107(9): 3772 - 3778.
[Abstract] [Full Text] [PDF]
The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone
Neal Flomenberg, Steven M. Devine, John F. DiPersio, Jane L. Liesveld, John M. McCarty, Scott D. Rowley, David H. Vesole, Karin Badel, and Gary Calandra
Blood 2005 106: 1867-1874. PDF
Lauri Burroughs, Marco Mielcarek, Marie-Térèse Little, Gary Bridger, Ron MacFarland, Simon Fricker, Jean Labrecque, Brenda M. Sandmaier, and Rainer Storb
Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral-blood mononuclear cells in a canine transplantation model
Blood, Dec 2005; 106: 4002 - 4008. PDF
Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
Blood, Oct 2003; 102: 2728 - 2730. PDF
G-CSF and AMD3100 Mobilize Monocytes into the Blood that Stimulate Angiogenesis In Vivo Through a Paracrine Mechanism
Blood, May 2006; doi:10.1182/blood-2006-04-013755 PDF
Jing Chen, André Larochelle, Simon Fricker, Gary Bridger, Cynthia E. Dunbar, and Janis L. Abkowitz
Mobilization as a preparative regimen for hematopoietic stem cell transplantation
Blood, May 2006; 107: 3764 - 3771. PDF
JiangFang Wang, Susanne Marschner, and Terri H. Finkel
CXCR4 engagement is required for HIV-1–induced L-selectin shedding
Blood, Feb 2004; 103: 1218 - 1221. PDF
Matthew Sharron, Stefan Pöhlmann, Ken Price, Elias Lolis, Monica Tsang, Frank Kirchhoff, Robert W. Doms, and Benhur Lee
Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes
Blood, Jul 2000; 96: 41 - 49. PDF
Susan F. Leitman
Progenitor cell mobilization gets a boost from CXCR4 inhibition
Blood, Sep 2005; 106: 1516 - 1517. PDF
