一個(gè)日美聯(lián)合研究小組日前利用人類毛囊干細(xì)胞，成功修復(fù)了實(shí)驗(yàn)鼠足部被切斷的神經(jīng),。該成果將有望應(yīng)用于人類手腳部位的神經(jīng)修復(fù),。
毛囊干細(xì)胞具備分化成毛發(fā)、神經(jīng),、肌肉和皮膚細(xì)胞的能力,。日本北里大學(xué)的研究人員和美國(guó)同行提取了人類毛囊干細(xì)胞并使其增殖，再把增殖后的細(xì)胞移植到實(shí)驗(yàn)鼠足部末梢神經(jīng)被切斷的部分,。8周后,，被切斷的實(shí)驗(yàn)鼠足部末梢神經(jīng)重新連接到一起，在電刺激下,，實(shí)驗(yàn)鼠的腳可以重新活動(dòng),。
研究人員介紹說(shuō)，雖然毛囊干細(xì)胞分化能力和形成器官的種類有限,，增殖能力也較低,，但這種干細(xì)胞移植后癌變風(fēng)險(xiǎn)較小，將來(lái)有望應(yīng)用于修復(fù)因脊髓損傷或事故造成斷裂的手腳部位神經(jīng),。（生物谷Bioon.com）
生物谷推薦原始出處：
J Cell Biochem. 2009 Jun 8
Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral-nerve injury: An advantageous alternative to ES and iPS cells.
Amoh Y, Kanoh M, Niiyama S, Hamada Y, Kawahara K, Sato Y, Hoffman RM, Katsuoka K.
Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.
The optimal source of stem cells for regenerative medicine is a major question. Embryonic stem (ES) cells have shown promise for pluripotency but have ethical issues and potential to form teratomas. Pluripotent stem cells have been produced from skin cells by either viral-, plasmid- or transposon-mediated gene transfer. These stem cells have been termed induced pluripotent stem cells or iPS cells. iPS cells may also have malignant potential and are inefficiently produced. Embryonic stem cells may not be suited for individualized therapy, since they can undergo immunologic rejection. To address these fundamental problems, our group is developing hair follicle pluripotent stem (hfPS) cells. Our previous studies have shown that mouse hfPS cells can differentiate to neurons, glial cells in vitro, and other cell types, and can promote nerve and spinal cord regeneration in vivo. hfPS cells are located above the hair follicle bulge in what we have termed the hfPS cell area (hfPSA) and are nestin positive and keratin 15 (K-15) negative. Human hfPS cells can also differentiate into neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. In the present study, human hfPS cells were transplanted in the severed sciatic nerve of the mouse where they differentiated into glial fibrillary-acidic-protein (GFAP)-positive Schwann cells and promoted the recovery of pre-existing axons, leading to nerve generation. The regenerated nerve recovered function and, upon electrical stimulation, contracted the gastrocnemius muscle. The hfPS cells can be readily isolated from the human scalp, thereby providing an accessible, autologous and safe source of stem cells for regenerative medicine that have important advantages over ES or iPS cells.
