雖然多細(xì)胞生物的很多不同細(xì)胞類型一旦分化之后保持穩(wěn)定對(duì)這些生物的成功很重要,,但在通過將體細(xì)胞暴露于一種所謂的“轉(zhuǎn)錄因子雞尾酒”來生成誘導(dǎo)多能干(iPS)細(xì)胞方面所取得的進(jìn)展卻凸顯了這樣一個(gè)事實(shí):幾乎任何細(xì)胞都有被重新編程的潛力,。這便提出了一個(gè)問題,;細(xì)胞類型之間的相互轉(zhuǎn)換是因生理原因出現(xiàn)的,還是在疾病背景下出現(xiàn)的,?
Thomas Graf 和Tariq Enver利用來自血液細(xì)胞系的例子來說明轉(zhuǎn)錄因子轉(zhuǎn)分化(transdifferentiation)的原理,,他們得出的結(jié)論是,轉(zhuǎn)分化從根本上來說是一個(gè)與分化類似,、與iPS重新編程不同的過程。他們假設(shè),,一個(gè)細(xì)胞類型向另一個(gè)的轉(zhuǎn)化可以作為一個(gè)正常發(fā)育過程發(fā)生,;同時(shí)他們還猜測(cè)了在再生醫(yī)學(xué)中對(duì)細(xì)胞系進(jìn)行強(qiáng)行重新編程的前景。(生物谷Bioon.com)
生物谷推薦原始出處:
Nature 462, 587-594 (3 December 2009) | doi:10.1038/nature08533
Forcing cells to change lineages
The ability to produce stem cells by induced pluripotency (iPS reprogramming) has rekindled an interest in earlier studies showing that transcription factors can directly convert specialized cells from one lineage to another. Lineage reprogramming has become a powerful tool to study cell fate choice during differentiation, akin to inducing mutations for the discovery of gene functions.