多國科學家組成的研究小組日前成功繪制了人體正常細胞中轉(zhuǎn)錄因子之間相互發(fā)揮作用的示意圖,。
研究人員調(diào)查了人體約2000種轉(zhuǎn)錄因子中的1222種。在這份示意圖中,，轉(zhuǎn)錄因子用點來表示,，如果兩種轉(zhuǎn)錄因子之間存在相互作用，就用線條把相應的兩個點連接起來,。最終,，所有的連接工作結(jié)束后，畫面出現(xiàn)一個大致的圓形,。
有了這份示意圖,，轉(zhuǎn)錄因子之間復雜的關(guān)系可以較清楚地呈現(xiàn)在人們面前,。研究人員表示，只要擁有必要的數(shù)據(jù),，癌細胞中轉(zhuǎn)錄因子之間的相互作用也能夠通過圖形表現(xiàn)出來,，以幫助專家推測癌細胞基因的活動,。
這一研究成果已發(fā)表在新一期美國學術(shù)期刊《細胞》上。（生物谷Bioon.com）
生物谷推薦原始出處：
Cell, Volume 140, Issue 5, 744-752, 5 March 2010 10.1016/j.cell.2010.01.044
An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man
Timothy Ravasi, Harukazu Suzuki, Carlo Vittorio Cannistraci, Shintaro Katayama, Vladimir B. Bajic, Kai Tan, Altuna Akalin, Sebastian Schmeier, Mutsumi Kanamori-Katayama, Nicolas Bertin, Piero Carninci, Carsten O. Daub, Alistair R.R. Forrest, Julian Gough, Sean Grimmond, Jung-Hoon Han, Takehiro Hashimoto, Winston Hide, Oliver Hofmann, Hideya Kawaji, Atsutaka Kubosaki, Timo Lassmann, Erik van Nimwegen, Chihiro Ogawa, Rohan D. Teasdale, Jesper Tegnér, Boris Lenhard, Sarah A. Teichmann, Takahiro Arakawa, Noriko Ninomiya, Kayoko Murakami, Michihira Tagami, Shiro Fukuda, Kengo Imamura, Chikatoshi Kai, Ryoko Ishihara, Yayoi Kitazume, Jun Kawai, David A. Hume, Trey Ideker, Yoshihide Hayashizaki
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution.
