加拿大阿爾伯塔大學(xué)的理查德·雷勒及其帶領(lǐng)的研究小組找到了降低血液中脂肪含量的新方法,，通過抑制一種被稱為甘油三酯水解酶（TGH）的活性,，可降低動物血脂含量，并改善葡萄糖的新陳代謝,。
在加拿大,，有60%的人身體超重甚至肥胖，肥胖癥已經(jīng)成為廣受關(guān)注的疾病,。肥胖癥引發(fā)的主要問題之一是血液中的脂肪水平增高,，這又是導(dǎo)致心血管病和脂肪肝以及Ⅱ型糖尿病的主要原因。
在動物身上的實驗還表明,，使用這種方法可以防止脂肪在肝臟等器官中的堆積,，避免脂肪肝的形成。同時,，降低TGH酶的活性還可以保護(hù)胰腺中的β細(xì)胞,，而胰腺正是身體生產(chǎn)胰島素的關(guān)鍵器官，因此該方法有助于減少肥胖病患者患糖尿病的風(fēng)險,。
研究人員表示,，該項發(fā)現(xiàn)表明TGH酶最終可以成為藥物標(biāo)靶，用于治療肥胖癥引發(fā)的代謝并發(fā)癥，有助于人們預(yù)防這些與肥胖癥相關(guān)的疾病,。研究成果發(fā)表在3月份出版的《細(xì)胞—代謝》雜志上,。 (生物谷Bioon.com)
生物谷推薦原文出處：
Cell Metabolism doi:10.1016/j.cmet.2010.02.005
Loss of TGH/Ces3 in Mice Decreases Blood Lipids, Improves Glucose Tolerance, and Increases Energy Expenditure
Enhui Wei, Yassine Ben Ali, James Lyon, Huajin Wang, Randy Nelson, Vernon W. Dolinsky, Jason R.B. Dyck, Grant Mitchell, Gregory S. Korbutt, Richard Lehner
Excessive accumulation of triacylglycerol in peripheral tissues is tightly associated with obesity and has been identified as an independent risk factor for insulin resistance, type 2 diabetes, and cardiovascular complications. Here we show that ablation of carboxylesterase 3 (Ces3)/triacylglycerol hydrolase (TGH) expression in mice (Tgh/) results in decreased plasma triacylglycerol, apolipoprotein B, and fatty acid levels in both fasted and fed states. Despite the attenuation of very low-density lipoprotein secretion, TGH deficiency does not increase hepatic triacylglycerol levels. Tgh/ mice exhibit increased food intake, respiratory quotient, and energy expenditure without change in body weight. These metabolic changes are accompanied by improved insulin sensitivity and glucose tolerance. Tgh/ mice have smaller sized pancreatic islets but maintain normal glucose-stimulated insulin secretion. These studies demonstrate the potential of TGH as a therapeutic target for lowering blood lipid levels.
