據(jù)5月21日的《科學(xué)》雜志報(bào)道說,，信號轉(zhuǎn)導(dǎo)通路，減少動(dòng)脈粥樣硬化（指的是在動(dòng)脈內(nèi)脂肪性斑塊的積聚）疾病中的膽固醇還可壓制與該疾病有關(guān)的白血球數(shù)量的增加,。
這些發(fā)現(xiàn)對動(dòng)脈粥樣硬化和白血球數(shù)增加的機(jī)制提供了線索，并可幫助改善對斑塊的危險(xiǎn)積聚的治療，因?yàn)檫@種積聚會(huì)引起冠心病,，而冠心病是美國首屈一指的死亡原因。
白細(xì)胞增多癥（即身體中白細(xì)胞數(shù)高于正常）是發(fā)生動(dòng)脈粥樣硬化的一個(gè)重要的驅(qū)動(dòng)因素,，但人們對其的發(fā)生機(jī)制仍然不甚清楚,。 Laurent Yvan-Charvet及其同僚如今顯示,，一組被稱作ATP結(jié)合匣式轉(zhuǎn)運(yùn)子的有名的蛋白質(zhì)是與粥樣硬化有關(guān)的白細(xì)胞增多癥的關(guān)鍵性的抑制物。
ATP結(jié)合匣式轉(zhuǎn)運(yùn)子可保護(hù)身體不發(fā)生動(dòng)脈粥樣硬化,，因?yàn)樗鼈兛纱龠M(jìn)那些充滿了脂肪物質(zhì)的細(xì)胞中的膽固醇從細(xì)胞內(nèi)外流,。 研究人員觀察到，那些缺乏2種轉(zhuǎn)運(yùn)子的小鼠的膽固醇水平會(huì)很高,，并且其斑塊積聚的速度也會(huì)加快,。
然而，這些有缺陷小鼠的疾病在存在有大量的HDL的時(shí)候（或稱“好”膽固醇）會(huì)被逆轉(zhuǎn),。 這些結(jié)果顯示,，那些已知的抑制動(dòng)脈內(nèi)斑塊積聚的信號轉(zhuǎn)導(dǎo)通路也可減輕白細(xì)胞增多癥。（生物谷Bioon.com）
Circulation：運(yùn)動(dòng)有助于保持白細(xì)胞端粒長度
NEJM：白細(xì)胞介素-2對治療HIV-AIDS無效
Nature Medicine：白細(xì)胞利用“DNA彈弓”抵御細(xì)菌感染
生物谷推薦原文出處：
Science DOI: 10.1126/science.1189731
ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation
Laurent Yvan-Charvet,1,*, Tamara Pagler,1,* Emmanuel L. Gautier,2 Serine Avagyan,2 Read L. Siry,1 Seongah Han,1 Carrie L. Welch,1 Nan Wang,1 Gwendalyn J. Randolph,2 Hans W. Snoeck,2 Alan R. Tall1
Elevated leukocyte cell numbers (leukocytosis), and monocytes in particular, promote atherosclerosis; however, how they become increased is poorly understood. Mice deficient in the ATP-binding cassette transporters ABCA1 and ABCG1, which promote cholesterol efflux from macrophages and suppress atherosclerosis in hypercholesterolemic mice, displayed leukocytosis, a transplantable myeloproliferative disorder, and a dramatic expansion of the stem and progenitor cell containing Lin–Sca-1+Kit+ (LSK) population in the bone marrow. Transplantation of Abca1–/– Abcg1–/– bone marrow into apoA-1 transgenic mice with high HDL suppressed the LSK population, reduced leukocytosis, and reversed both the myeloproliferative disorder and accelerated atherosclerosis. The findings indicate that ABCA1, ABCG1, and HDL inhibit the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of these populations with leukocytosis and accelerated atherosclerosis.
1 Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA.
2 Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
