研究人員報(bào)告說(shuō),，隱藏在硅納米線中的納米尺度的晶體管收音機(jī)可潛入活體細(xì)胞并監(jiān)控它們的活動(dòng),。 這些發(fā)夾形狀的納米線的末端附著在某個(gè)金屬平臺(tái)上，它們有可能與某臺(tái)計(jì)算機(jī)連接以監(jiān)控諸如搏動(dòng)心肌細(xì)胞或放電神經(jīng)元等可產(chǎn)生電脈沖的細(xì)胞的健康狀況,。
或者將來(lái)有一天，如果研究人員能夠在這些納米線的彎曲末端加上蛋白質(zhì)受體的話，它也許還能夠?qū)崟r(shí)記錄某個(gè)細(xì)胞所產(chǎn)生的核酸或其它分子,。 Bozhi Tian及其同事在合成硅納米線的過(guò)程中融入了一個(gè)納米尺度場(chǎng)效應(yīng)的晶體管。（這種方法涉及到更像典型有機(jī)化學(xué)的構(gòu)象控制,，它背離了制造半導(dǎo)體的常規(guī)方法,，而這些常規(guī)的方法所產(chǎn)生的裝置要大得多。） 研究人員還在該納米線的攜帶晶體管的部分引入了一個(gè)銳角彎曲,，并給予其一種細(xì)胞膜的覆蓋,，這樣，該尖端可進(jìn)入一個(gè)活細(xì)胞內(nèi),。細(xì)胞電壓的波動(dòng)接著會(huì)誘導(dǎo)該晶體管表面的電壓的變化,。
文章的作者證明，他們的裝置通過(guò)被結(jié)合到培養(yǎng)的雞心肌細(xì)胞中而發(fā)揮作用,，該裝置可記錄到這些心肌細(xì)胞的搏動(dòng),。（生物谷Bioon.com）
生物谷推薦原文出處：
Science DOI: 10.1126/science.1192033
Three-Dimensional, Flexible Nanoscale Field-Effect Transistors as Localized Bioprobes
Bozhi Tian,1,* Tzahi Cohen-Karni,2,* Quan Qing,1 Xiaojie Duan,1 Ping Xie,1 Charles M. Lieber1,2,
Nanoelectronic devices offer substantial potential for interrogating biological systems, although nearly all work has focused on planar device designs. We have overcome this limitation through synthetic integration of a nanoscale field-effect transistor (nanoFET) device at the tip of an acute-angle kinked silicon nanowire, where nanoscale connections are made by the arms of the kinked nanostructure, and remote multilayer interconnects allow three-dimensional (3D) probe presentation. The acute-angle probe geometry was designed and synthesized by controlling cis versus trans crystal conformations between adjacent kinks, and the nanoFET was localized through modulation doping. 3D nanoFET probes exhibited conductance and sensitivity in aqueous solution, independent of large mechanical deflections, and demonstrated high pH sensitivity. Additionally, 3D nanoprobes modified with phospholipid bilayers can enter single cells to allow robust recording of intracellular potentials.
1 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
2 School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
