瑞典卡羅林斯卡醫(yī)學(xué)院研究人員8日報告說,，他們研究發(fā)現(xiàn)一類名為室管膜細胞的干細胞不僅可幫助生成更多新的脊髓細胞,，還能幫助恢復(fù)脊髓功能。這一成果將有助于研究人員尋找治療人類各種脊髓損傷的新療法,。
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研究人員在新一期美國《細胞－干細胞》雜志上介紹說,，他們對實驗鼠的研究發(fā)現(xiàn)，一旦老鼠的骨髓組織受損,，存在于骨髓中的室管膜細胞就會被激活,，和一些其他類型的細胞一起，促使分化形成更多的新的骨髓細胞,，成為生成新骨髓細胞的“主要來源”,。
因此研究人員猜測，也許能夠篩選出一種藥物,，在脊髓受損后,，能夠有選擇地刺激室管膜細胞，使它分化形成更多的支持細胞,，少分化疤痕組織細胞,，從而更好地幫助受損脊髓恢復(fù)功能。(生物谷Bioon.com)
生物谷推薦英文摘要：
Cell Stem Cell doi:10.1016/j.stem.2010.07.014
Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
Fanie Barnabé-Heider, Christian G?ritz, Hanna Sabelstr?m, Hirohide Takebayashi, Frank W. Pfrieger, Konstantinos Meletis, Jonas FrisénSee Affiliations
Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. We have assessed the origin of new cells in the adult mouse spinal cord by genetic fate mapping. Oligodendrocyte progenitors self-renew, give rise to new mature oligodendrocytes, and constitute the dominating proliferating cell population in the intact adult spinal cord. In contrast, astrocytes and ependymal cells, which are restricted to limited self-duplication in the intact spinal cord, generate the largest number of cells after spinal cord injury. Only ependymal cells generate progeny of multiple fates, and neural stem cell activity in the intact and injured adult spinal cord is confined to this cell population. We provide an integrated view of how several distinct cell types contribute in complementary ways to cell maintenance and the reaction to injury.
