據(jù)外媒報道,，美國科學家利用生物干細胞技術(shù),，利用兩只公鼠培養(yǎng)出“后代”,。這一實驗的成功將有助于保護瀕危物種,，甚至可以幫助同性伴侶擁有屬于雙方的孩子,。
Biology of Reproduction 在12月8日刊發(fā)的文章稱,，美國德得克薩斯州安德森癌癥中心的科學家從一個公鼠(XY)胎兒的干細胞中，制造出一個誘導多能干細胞系(IPS),。
這些誘導多能干細胞是由成熟的干細胞經(jīng)歷基因重組,，形成類似胚胎干細胞的狀態(tài)。
這些誘導多能干細胞中的一些在成長過程中,，自行失去了Y染色體,，轉(zhuǎn)變成XO細胞。
這些XO細胞之后被注入老鼠胚胎內(nèi),，再移植到代孕母鼠體內(nèi),，生產(chǎn)出攜帶原來公鼠身上的X染色體子鼠。
之后,，這些新生的小老鼠中的母鼠跟正常的公鼠交配,，它們的孩子、無論公鼠還是母鼠,，都會同時攜帶兩個“父親”的基因,。
研究者們還稱，通過這一技術(shù),，也可以生產(chǎn)出含有兩個母鼠基因的子鼠,。
然而，這項研究中還介紹,，這一技術(shù)用在人身上還需要很長的時間,。
目前，對于人類的誘導突變干細胞的利用還受到嚴格限制,。（生物谷Bioon.com）
生物谷推薦原文出處：
Biology of Reproduction doi: 10.1095/biolreprod.110.088831
Generation of Viable Male and Female Mice from Two Fathers
Jian Min Deng, Kei Satoh, Hao Chang, Zhaoping Zhang, M. David Stewart, Hongran Wang, Austin J. Cooney and Richard R. Behringer
Abstract
In sexual species, fertilization of oocytes produces individuals with alleles derived from both parents. Here we use pluripotent stem cells derived from somatic cells to combine the haploid genomes from two males to produce viable sons and daughters. Male (XY) mouse induced pluripotent stem (iPS) cells (Father #1) were used to isolate subclones that had spontaneously lost the Y chromosome to become genetically female (XO). These male-derived XO stem cells were used to generate female chimeras that were bred with genetically distinct males (Father #2), yielding progeny possessing genetic information that was equally derived from both fathers. Thus, functional oocytes can be generated from male somatic cells after reprogramming and spontaneous sex reversal. These findings have novel implications for mammalian reproduction and assisted reproductive technology.
