細(xì)胞分裂過程需要一系列有序的事件來確保遺傳信息的正確復(fù)制及其準(zhǔn)確分布。這種復(fù)制周期的調(diào)控非常復(fù)雜,，使得了解其關(guān)鍵原理很困難,。為了研究真核細(xì)胞有絲分裂周期的核心引擎,，Damien Coudreuse 和 Paul Nurse在裂殖酵母中生成了一個(gè)高度簡(jiǎn)化的最小控制網(wǎng)絡(luò)?；谟没蚬こ谭椒ㄗ龀傻膯我籆DK（依賴于細(xì)胞周期蛋白的激酶）振蕩器的這個(gè)體系,，在沒有那些在能夠完全發(fā)揮功能的細(xì)胞中起作用的很多已知的調(diào)控性輸入和反饋存在的情況下，實(shí)現(xiàn)了細(xì)胞周期中主要事件的有序演進(jìn),。（生物谷Bioon.com）

生物谷推薦原文出處：

Nature    doi:10.1038/nature09543

Driving the cell cycle with a minimal CDK control network

Damien Coudreuse& Paul Nurse

Control of eukaryotic cell proliferation involves an extended regulatory network, the complexity of which has made it difficult to understand the basic principles of the cell cycle. To investigate the core engine of the mitotic cycle we have generated a minimal control network in fission yeast that efficiently sustains cellular reproduction. Here we demonstrate that orderly progression through the major events of the cell cycle can be driven by oscillation of an engineered monomolecular cyclin-dependent protein kinase (CDK) module lacking much of the canonical regulation. We show further that the CDK oscillator acts as the primary organizer of the cell cycle, imposing timing and directionality to a system of two CDK activity thresholds that define independent cell cycle phases. We propose that this simple core architecture forms the basic control of the eukaryotic cell cycle.