人體皮膚受傷后,，骨髓干細胞會趕到傷口處并變身成皮膚細胞，修復(fù)損傷,。但骨髓干細胞是受到誰的指揮呢,？英國和日本科學(xué)家最近發(fā)現(xiàn)了這個“指揮員”——HMGB1蛋白質(zhì),。
英國倫敦國王學(xué)院的約翰·麥格拉思在最新一期 PNAS 上報告說，皮膚受損時,，人體就會釋放出HMGB1蛋白質(zhì),。這種蛋白質(zhì)會吹響召集骨髓干細胞前來支援的“集合號”，之后骨髓干細胞就會趕來完成修復(fù)工作,。
麥格拉思還發(fā)現(xiàn),，除了受傷外，植皮手術(shù)也會刺激人體釋放出更多的HMGB1蛋白質(zhì),。這說明，移植皮膚不僅可以起到覆蓋傷口的作用,，還可以調(diào)動人體內(nèi)部潛能,，促進康復(fù)。
麥格拉思希望,，在此次發(fā)現(xiàn)的基礎(chǔ)上研發(fā)藥物,，以找到修復(fù)受損皮膚的新方法。（生物谷Bioon.com）
生物谷推薦原文出處：
PNAS doi: 10.1073/pnas.1016753108
PDGFRα-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia
Katsuto Tamaia,1, Takehiko Yamazakia, Takenao Chinoa, Masaru Ishiib, Satoru Otsurua, Yasushi Kikuchia, Shin Iinumaa, Kotaro Sagaa, Keisuke Nimuraa, Takashi Shimboa, Noriko Umegakic, Ichiro Katayamac, Jun-ichi Miyazakid, Junji Takedae, John A. McGrathf, Jouni Uittog, and Yasufumi Kanedaa,1
Abstract
The role of bone marrow cells in repairing ectodermal tissue, such as skin epidermis, is not clear. To explore this process further, this study examined a particular form of cutaneous repair, skin grafting. Grafting of full thickness wild-type mouse skin onto mice that had received a green fluorescent protein-bone marrow transplant after whole body irradiation led to an abundance of bone marrow-derived epithelial cells in follicular and interfollicular epidermis that persisted for at least 5 mo. The source of the epithelial progenitors was the nonhematopoietic, platelet-derived growth factor receptor α-positive (Lin?/PDGFRα+) bone marrow cell population. Skin grafts release high mobility group box 1 (HMGB1) in vitro and in vivo, which can mobilize the Lin?/PDGFRα+ cells from bone marrow to target the engrafted skin. These data provide unique insight into how skin grafts facilitate tissue repair and identify strategies germane to regenerative medicine for skin and, perhaps, other ectodermal defects or diseases.
