在植物的莖端分生組織（SAM）的干細胞是葉,、莖和花等器官形成的自我再生的源頭。在自然界中,，盡管局部感染,，無病植物可從SAM更新,，這正是幾十年來園藝實踐的基礎(chǔ)所在。然而SAM免疫性的分子基礎(chǔ)仍不清楚,。
美國科學(xué)家Horim Lee等發(fā)現(xiàn),，在擬南芥SAM中，CLAVATA3肽（CLV3p）從莖干細胞表達分泌,，其表現(xiàn)的莖干細胞動態(tài)平衡關(guān)鍵調(diào)節(jié)功能可通過鞭毛蛋白受體激酶（FLS2）觸發(fā)免疫信號和病原體抗性,。CLV3p–FLS2信號獨立于由CLV1 和CLV2受體介導(dǎo)的莖干細胞通路，并從FLS2 介導(dǎo)的生長抑制中解耦,。內(nèi)源的CLV3p在SAM中的感應(yīng)是通過細菌鞭毛蛋白FLS2的模式識別受體執(zhí)行,，打破了先天免疫中預(yù)先定義的自我與非自我識別。CLV3p的雙重識別感應(yīng)闡明了植物肽與受體激酶信號在發(fā)展與免疫中的共進化,。在SAM或者生殖系統(tǒng)增強免疫力可能代表了植物與動物永續(xù)發(fā)展的一個共適的策略,。（生物谷Bioon.com）
生物谷推薦原文出處：
Nature (2011) Published online 17 April 2011 doi:10.1038/nature09958
Stem-cell-triggered immunity through CLV3p–FLS2 signalling
Horim Lee,1 Ok-Kyong Chah1 & Jen Sheen1
Stem cells in the shoot apical meristem (SAM) of plants are the self-renewable reservoir for leaf, stem and flower organogenesis1, 2. In nature, disease-free plants can be regenerated from SAM despite infections elsewhere, which underlies a horticultural practice for decades3. However, the molecular basis of the SAM immunity remains unclear. Here we show that the CLAVATA3 peptide (CLV3p), expressed and secreted from stem cells and functioning as a key regulator of stem-cell homeostasis in the SAM of Arabidopsis1, 2, 4, can trigger immune signalling and pathogen resistance via the flagellin receptor kinase FLS2 (refs 5, 6). CLV3p–FLS2 signalling acts independently from the stem-cell signalling pathway mediated through CLV1 and CLV2 receptors1, 2, 4, and is uncoupled from FLS2-mediated growth suppression5, 6. Endogenous CLV3p perception in the SAM by a pattern recognition receptor for bacterial flagellin, FLS2, breaks the previously defined self and non-self discrimination in innate immunity6, 7. The dual perception of CLV3p illustrates co-evolution of plant peptide and receptor kinase signalling for both development and immunity. The enhanced immunity in SAM or germ lines may represent a common strategy towards immortal fate in plants and animals1, 2, 8.
