英國《自然》雜志網(wǎng)站8日報告說，劍橋大學科學家在世界上首次培育出了哺乳動物的單倍體胚胎干細胞，這項成果將會極大推動基因研究,。
包括人在內(nèi)的哺乳動物都是雙倍體，也就是細胞中有兩套染色體,，一套來自父方,，一套來自母方。然而,，雙倍體對于基因研究來說,，是個巨大困難，因為科學家很難確定動物的某一性狀是哪一套染色體決定的,。
此次,，劍橋大學科學家利用實驗鼠的卵細胞，首次成功培育出了哺乳動物的單倍體胚胎干細胞,。
參與這一研究的科學家安東·伍茲說,，胚胎干細胞能夠分化成各種組織和器官，因此這項成果意味著,，科學家有可能可以準確跟蹤某一基因?qū)游镄誀畹拈L期作用,，這將有力提高基因研究的準確性。(生物谷 Bioon.com)
doi:10.1038/nature10448
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Derivation of haploid embryonic stem cells from mouse embryos
Anton Wutz ,、Martin Leeb
Most animals are diploid, but haploid-only and male-haploid (such as honeybee and ant) species have been described. The diploid genomes of complex organisms limit genetic approaches in biomedical model species such as mice. To overcome this problem, experimental induction of haploidy has been used in fish . Haploid development in zebrafish has been applied for genetic screening. Recently, haploid pluripotent cell lines from medaka fish (Oryzias latipes) have also been established. In contrast, haploidy seems less compatible with development in mammals. Although haploid cells have been observed in egg cylinder stage parthenogenetic mouse embryos, most cells in surviving embryos become diploid. Here we describe haploid mouse embryonic stem cells and show their application in forward genetic screening.
