近日,，中國(guó)科學(xué)院北京基因組研究所基因組科學(xué)與信息重點(diǎn)實(shí)驗(yàn)室的“百人計(jì)劃”研究員章張及其團(tuán)隊(duì),，與沙特阿卜杜拉國(guó)王科技大學(xué)（King Abdullah University of Science and Technology）開(kāi)展科研合作，對(duì)長(zhǎng)非編碼RNA的分類問(wèn)題進(jìn)行了系統(tǒng)綜述,，相關(guān)論文在RNA Biology發(fā)表,。
長(zhǎng)非編碼RNA是近期發(fā)現(xiàn)的一大類非編碼RNA（長(zhǎng)度普遍大于200nt,，故籠統(tǒng)稱之為長(zhǎng)非編碼RNA）,。其在細(xì)胞內(nèi)普遍轉(zhuǎn)錄并大量存在,，并在多個(gè)生命過(guò)程中發(fā)揮重要作用。
根據(jù)目前所得數(shù)據(jù),，長(zhǎng)非編碼RNA缺乏顯著序列特征,，與蛋白編碼RNA及miRNA相比較，其物種間序列保守性較差,，嚴(yán)重阻礙了大規(guī)模生物信息學(xué)及功能研究,。為促進(jìn)長(zhǎng)非編碼RNA的生物學(xué)特征及生物學(xué)意義的研究，研究人員從基因組位置,、對(duì)DNA序列的影響,、功能分類、與靶基因結(jié)合特征等不同方面探討了長(zhǎng)非編碼RNA的分類,，并研究了不同分類方法之間所存在的聯(lián)系,。
長(zhǎng)非編碼RNA的準(zhǔn)確分類將對(duì)某一類特定長(zhǎng)非編碼RNA的研究、在不同類別的長(zhǎng)非編碼RNA上提出假設(shè)及挖掘長(zhǎng)非編碼RNA功能等方面提供有力的幫助與借鑒,，因而在長(zhǎng)非編碼RNA的研究上具有重要意義,。（生物谷Bioon.com）
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On the classification of long non-coding RNAs.
Ma L, Bajic VB, Zhang Z.
Long non-coding RNAs (lncRNAs) have been found to perform various functions in a wide variety of important biological processes. To make easier interpretation of lncRNA functionality and conduct deep mining on these transcribed sequences, it is convenient to classify lncRNAs into different groups. Here, we summarize classification methods of lncRNAs according to their four major features, namely, genomic location and context, effect exerted on DNA sequences, mechanism of functioning and their targeting mechanism. In combination with the presently available function annotations, we explore potential relationships between different classification categories, and generalize and compare biological features of different lncRNAs within each category. Finally, we present our view on potential further studies. We believe that the classifications of lncRNAs as indicated above are of fundamental importance for lncRNA studies, helpful for further investigation of specific lncRNAs, for formulation of new hypothesis based on different features of lncRNA and for exploration of the underlying lncRNA functional mechanisms.
