“泛素連接酶”Parkin是“泛素化”和線粒體自吞（受損線粒體的清除中所涉及的自吞類型）所必需的,。這項研究顯示,，Parkin也在先天免疫防御中起作用，用“泛素鏈”來標記含結(jié)核分枝桿菌的吞噬體,，并將它們作為異體吞噬（應對細胞內(nèi)細菌病原體的自吞降解過程）的目標,。鑒于線粒體的演化起源被假設是來自一個細菌內(nèi)共生體，因此Parkin調(diào)控用于內(nèi)源性線粒體（自身）的質(zhì)量控制和有害細菌病原體（非自身）的清除的同一細胞程序的這個事實是意味深長的,。(生物谷 Bioon.com)

生物谷推薦的英文摘要

 
Nature  doi:10.1038/nature12566

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

Paolo S. Manzanillo,1 Janelle S. Ayres,2, 8 Robert O. Watson,1, 8 Angela C. Collins,3 Gianne Souza,1 Chris S. Rae,4 David S. Schneider,5 Ken Nakamura,6, 7 Michael U. Shiloh3 & Jeffery S. Cox1

Ubiquitin-mediated targeting of intracellular bacteria to the autophagy pathway is a key innate defence mechanism against invading microbes, including the important human pathogen Mycobacterium tuberculosis. However, the ubiquitin ligases responsible for catalysing ubiquitin chains that surround intracellular bacteria are poorly understood. The parkin protein is a ubiquitin ligase with a well-established role in mitophagy, and mutations in the parkin gene (PARK2) lead to increased susceptibility to Parkinson’s disease. Surprisingly, genetic polymorphisms in the PARK2 regulatory region are also associated with increased susceptibility to intracellular bacterial pathogens in humans, including Mycobacterium leprae and Salmonella enterica serovar Typhi, but the function of parkin in immunity has remained unexplored. Here we show that parkin has a role in ubiquitin-mediated autophagy of M. tuberculosis. Both parkin-deficient mice and flies are sensitive to various intracellular bacterial infections, indicating parkin has a conserved role in metazoan innate defence. Moreover, our work reveals an unexpected functional link between mitophagy and infectious disease.