初級纖毛是一種非運(yùn)動(dòng)性信號作用細(xì)胞器,，見于胞質(zhì)膜的一個(gè)特定區(qū)域,，在那里它發(fā)揮兩個(gè)功能：信號傳導(dǎo)和探測環(huán)境提示如營養(yǎng)物水平等。本期Nature上發(fā)表的兩篇互補(bǔ)的論文描述了纖毛生成與自吞作用之間的一個(gè)新穎聯(lián)系,。Zaiming Tang等人發(fā)現(xiàn),，在“中心粒隨體”上發(fā)生的纖毛形成過程的一個(gè)負(fù)調(diào)控因子（即“oral-facial-digital syndrome 1”，縮寫為OFD1）的自吞降解,，促進(jìn)初級纖毛的生物生成,。Olatz Pampliega等人揭示了纖毛生成與自吞作用之間的一個(gè)互惠關(guān)系，發(fā)現(xiàn)初級纖毛是由饑餓誘導(dǎo)的自吞作用的激發(fā)所需的,，而且自吞作用負(fù)調(diào)控纖毛生成,。初級纖毛和自吞作用通道之間的“交流”也許會(huì)進(jìn)而導(dǎo)致我們對人類纖毛疾病的認(rèn)識。(生物谷：Bioon.com)

生物谷推薦的英文摘要

 
Nature   doi: 10.1038/nature12639

Functional interaction between autophagy and ciliogenesis

Olatz Pampliega,Idil Orhon,Bindi Patel,Sunandini Sridhar,Antonio Díaz-Carretero,Isabelle Beau,Patrice Codogno,Birgit H. Satir,Peter Satir&Ana Maria Cuervo

Nutrient deprivation is a stimulus shared by both autophagy and the formation of primary cilia. The recently discovered role of primary cilia in nutrient sensing and signalling motivated us to explore the possible functional interactions between this signalling hub and autophagy. Here we show that part of the molecular machinery involved in ciliogenesis also participates in the early steps of the autophagic process. Signalling from the cilia, such as that from the Hedgehog pathway, induces autophagy by acting directly on essential autophagy-related proteins strategically located in the base of the cilium by ciliary trafficking proteins. Whereas abrogation of ciliogenesis partially inhibits autophagy, blockage of autophagy enhances primary cilia growth and cilia-associated signalling during normal nutritional conditions. We propose that basal autophagy regulates ciliary growth through the degradation of proteins required for intraflagellar transport. Compromised ability to activate the autophagic response may underlie some common ciliopathies.