生物谷報道：本期Nature報道了在體研究靜息狀態(tài)的神經(jīng)干細胞對Sonic hedgehog （SHH）信號的反應機制。這為揭示為什么成體干細胞能在組織內(nèi)終生存在,，但并不會出現(xiàn)增殖或分化的機理。
Sonic hedgehog (Shh) has been implicated in the ongoing neurogenesis in postnatal rodent brains1, 2. Here we adopted an in vivo genetic fate-mapping strategy, using Gli1 (GLI-Kruppel family member) as a sensitive readout of Shh activity, to systematically mark and follow the fate of Shh-responding cells in the adult mouse forebrain. We show that initially, only a small population of cells (including both quiescent neural stem cells and transit-amplifying cells) responds to Shh in regions undergoing neurogenesis. This population subsequently expands markedly to continuously provide new neurons in the forebrain. Our study of the behaviour of quiescent neural stem cells provides in vivo evidence that they can self-renew for over a year and generate multiple cell types. Furthermore, we show that the neural stem cell niches in the subventricular zone and dentate gyrus are established sequentially and not until late embryonic stages.
原文來源：
Sohyun Ahn and Alexandra L. Joyner. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 437, 894-897 (6 October 2005)
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