肝臟再生是與細(xì)胞轟動(dòng)、脂質(zhì)代謝和細(xì)胞分裂相一致的一種事先編排好的細(xì)胞應(yīng)答,。來(lái)自西班牙,、澳大利亞和德國(guó)三國(guó)的科學(xué)家發(fā)現(xiàn)caveolin-1基因被破壞的小鼠模型（cav1–/–小鼠），其肝臟再生受損,，并且在進(jìn)行部分肝臟切除手術(shù)后的存活率也明顯下降,。這些發(fā)現(xiàn)公布在最新一期（9月15日）的《科學(xué)》雜志上。
這種特殊的小鼠模型的肝細(xì)胞中脂質(zhì)液滴的聚集明顯減少,。當(dāng)研究人員用葡萄糖（葡萄糖比脂質(zhì)相比是一種占主導(dǎo)底物的能量物質(zhì)）治療這種小鼠時(shí),，小鼠手術(shù)后的存活呂顯著上升，并且細(xì)胞周期進(jìn)程再次變得穩(wěn)定,。
這些試驗(yàn)結(jié)果表明caveolin-1在協(xié)調(diào)脂質(zhì)代謝和在細(xì)胞損傷發(fā)生后的肝臟中擴(kuò)增應(yīng)答（再生）的機(jī)制中起到關(guān)鍵作用,。這種肝細(xì)胞再生的關(guān)鍵物質(zhì)的發(fā)現(xiàn)，為提高肝臟切除患者存活率以及治療肝臟疾病患者提供了一種可能的靶標(biāo),。
部分英文原文：
Caveolin-1 Is Essential for Liver Regeneration
Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1 gene–disrupted mice (cav1–/– mice) exhibited impaired liver regeneration and low survival after a partial hepatectomy. Hepatocytes showed dramatically reduced lipid droplet accumulation and did not advance through the cell division cycle. Treatment of cav1–/– mice with glucose (which is a predominant energy substrate when compared to lipids) drastically increased survival and reestablished progression of the cell cycle. Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury.
