一項(xiàng)新的研究揭示了真核細(xì)胞中翻譯過程的起始因子(Initiation Factor,;IF)4A,,即eIF4A(eukaryotic translation initiation factor 4A)在抑制Decapentaplegic(Dpp)信號(hào)通路過程中的作用。在Dpp信號(hào)通路的激活過程中,,eIF4A通過非翻譯依賴性的方式,,促進(jìn)了下游信號(hào)成員Mad 和Medea的降解,。感興趣的讀者可以查閱英文原文,。
深入閱讀:
1.eIF4A goes beyond translation
Nature Cell Biology - 8, 1319 - 1321 (2006)
Markus Affolter & George Pyrowolakis
2.A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation
Nature Cell Biology - 8, 1407 - 1414 (2006)
Jinghong Li & Willis X. Li