生物谷報(bào)道：心臟增大或心肌肥大是對(duì)工作量增大的一種生理反應(yīng),，幫助維持心臟功能,。然而，如果這種狀況時(shí)間長(zhǎng)了,，它會(huì)發(fā)展成心臟衰竭,。在用一個(gè)心肌肥大小鼠模型所做的一項(xiàng)研究中，研究人員對(duì)這種轉(zhuǎn)變是如何發(fā)生的有了新的認(rèn)識(shí),。研究結(jié)果發(fā)表在最新一期的《Nature》雜志上,。
研究發(fā)現(xiàn)，當(dāng)實(shí)驗(yàn)動(dòng)物心臟增大時(shí),，會(huì)形成新的血管來(lái)支持它,。但大約兩星期后,，腫瘤抑制蛋白P53會(huì)在心臟細(xì)胞中積累，血管形成被阻斷,，小鼠出現(xiàn)心臟衰竭,。通過(guò)抑制P53或通過(guò)促進(jìn)血管形成來(lái)影響這一過(guò)程，也許可以成為阻止心肌肥大向心臟衰竭發(fā)展的一種手段,。
FIGURE 1. Cardiac hypertrophy, function and angiogenesis after TAC
a, Heart weight/body weight (HW/BW) after TAC. b, Cross-sectional area (CSA) of cardiomyocytes and the number of microvessels per cardiomyocyte. c, Double-immunostaining for dystrophin (brown) and PECAM (black) of the TAC hearts. Scale bar, 20 m. d, Echocardiographic analysis. FS, fractional shortening; LVPWTd, left ventricular posterior wall thickness. Asterisk, P < 0.05, two asterisks, P < 0.001 versus day 0; dagger, P < 0.01 versus day 14. Error bars indicate s.e.m.; n = 7 for a; n = 3 for b; n = 5 for d. e, Cardiac fibrosis. Scale bar, 50 m. f, g, RNase protection assay (f) and western blot analysis (g) in the TAC heart.
原文出處：
Nature Volume 446 Number 7134
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload p444
Masanori Sano, Tohru Minamino, Haruhiro Toko, Hideyuki Miyauchi, Masayuki Orimo, Yingjie Qin, Hiroshi Akazawa, Kaoru Tateno, Yosuke Kayama, Mutsuo Harada, Ippei Shimizu, Takayuki Asahara, Hirofumi Hamada, Shuhei Tomita, Jeffrey D. Molkentin, Yunzeng Zou and Issei Komuro
doi:10.1038/nature05602
First paragraph | Full Text | PDF (681K) | Supplementary information
See also: Editor's summary
相關(guān)基因：
HIF1A
Official Symbol: HIF1A and Name: hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens]
Other Aliases: HIF-1alpha, HIF1-ALPHA, MOP1, PASD8
Other Designations: ARNT interacting protein; hypoxia-inducible factor 1, alpha subunit; member of PAS superfamily 1
Chromosome: 14; Location: 14q21-q24
MIM: 603348
GeneID: 3091
TP53
Official Symbol: TP53 and Name: tumor protein p53 (Li-Fraumeni syndrome) [Homo sapiens]
Other Aliases: LFS1, TRP53, p53
Other Designations: p53 tumor suppressor; tumor protein p53
Chromosome: 17; Location: 17p13.1
MIM: 191170
GeneID: 7157
