生物谷報道：心臟病發(fā)作后幸存下來的病人,，其大面積的組織是創(chuàng)傷后修復的,。Thomas Jefferson 大學和Alfred I. DuPont 兒童醫(yī)院的研究者已經(jīng)證實有一種蛋白，它可以在心臟病發(fā)作后促進損傷的修復過程,。研究者們在紐奧爾良市于3.27一年一度的美國學院的科學會議上提出了這項研究,。他們應用小鼠來研究纖連蛋白-2（一種細胞外基質(zhì)蛋白），以便更好的理解它在損傷修復中所發(fā)揮的作用,。纖連蛋白-2存在于胚胎發(fā)育和各種損傷后組織重塑過程中,。細胞外基質(zhì)為組織細胞提供一種連接，可能在損傷后的組織重塑過程中提供結(jié)構(gòu)上的完整性,，但關(guān)于其功能還知之甚少,。
通過比較正常的和缺乏纖連蛋白-2的小鼠在心臟病發(fā)作后24和72小時的心臟創(chuàng)傷的結(jié)果，研究者發(fā)現(xiàn),，缺乏纖連蛋白-2的小鼠其急性損傷修復大大延遲,。72小時后，他們發(fā)現(xiàn)缺乏纖連蛋白-2的小鼠其梗死的面積大于比正常的小鼠,。缺乏纖連蛋白-2的小鼠心臟病發(fā)作后的損傷修復過程比較慢,，是由于延緩了損傷區(qū)域瘢痕組織的形成。這項研究表明,，纖連蛋白-2促進心臟損傷修復可能與一種促損傷修復的生長因子TGF的幫助有關(guān),。
研究者目前正在研究纖連蛋白-2在慢性心力衰竭的過程中的作用。
原文出處：
Extracellular Matrix Protein, Fibulin-2, Enhances Acute Wound Healing After Experimental Myocardial Infarction In Mice
After surviving a heart attack, a big issue for a patient is the healing of the wound. Researchers at Thomas Jefferson University and Alfred I. DuPont Hospital for Children have found something that may help; they've identified a protein that contributes to the wound healing process after a heart attack.
The researchers presented the study at the American College of Cardiology's 56th Annual Scientific Session in New Orleans on March 27 at 10 am (abstract 1025-75).
They used mice to examine the role of Fibulin-2, an extracellular matrix protein, to better understand its role in wound repair. Fibulin-2 is naturally occurring in embryonic development as well as in tissue remodeling after various injuries.
Extracellular matrix, which embraces and connects cells within the tissue, may provide structural integrity during tissue remodeling after injury, but little is known about its functional aspects.
By comparing the results of heart attacks in mice that did not have the Fibulin-2 protein with normal mice at both 24 and 72 hours after the heart attack, the researchers found that acute wound healing was significantly delayed in the mice lacking Fibulin-2. After 72 hours, they found that the damaged (infarct) area was much larger in the mice lacking Fibulin-2.
The researchers found that the wound healing process was much slower in the mice lacking Fibulin-2 after a heart attack due to delayed scar tissue formation in the damaged area. The study demonstrated that Fibulin-2 facilitates heart wound healing probably with the help of (TGF)-?, a growth factor that promotes wound healing.
The researchers are also currently looking into the role of Fibulin-2 as a factor in the development of chronic heart failure.
http://www.medicalnewstoday.com/medicalnews.php?newsid=66455
相關(guān)基因：
LOC131984
similar to fibulin 2 precursor; Fibulin-2 (H. sapiens) [Homo sapiens]
Chromosome: 3; Location: 3p25.1
GeneID: 131984
This record was discontinued.
