對成分相同的藥物來說，線形納米顆粒藥物比球形狀藥物在血液里循環(huán)的時間更長,，新研究成果發(fā)表在4月號的《自然—納米技術》上，這表明在癌癥治療的藥物傳輸器設計中,，形狀的考慮很重要,。
Dennis Discher和同事發(fā)現，柔軟的絲狀聚合體在小鼠和老鼠體內循環(huán)的時間可長達一周,，而球形的納米顆?；蚱渌裉技{米管結構的顆粒在體內循環(huán)的時間只有幾個小時。循環(huán)時間的長短取決于絲狀部分如何隨液體流動,，以及它們與細胞間的相互作用,。
部分英文原文：
Nature Nanotechnology 2, 249 - 255 (2007)
Published online: 25 March 2007 | doi:10.1038/nnano.2007.70
Subject Categories: Nanobiotechnology | Nanomedicine | Nanoparticles
Shape effects of filaments versus spherical particles in flow and drug delivery
Yan Geng1,3, Paul Dalhaimer1,3, Shenshen Cai1, Richard Tsai1, Manorama Tewari1, Tamara Minko2 & Dennis E. Discher1
Abstract
Interaction of spherical particles with cells and within animals has been studied extensively, but the effects of shape have received little attention. Here we use highly stable, polymer micelle assemblies known as filomicelles to compare the transport and trafficking of flexible filaments with spheres of similar chemistry. In rodents, filomicelles persisted in the circulation up to one week after intravenous injection. This is about ten times longer than their spherical counterparts and is more persistent than any known synthetic nanoparticle. Under fluid flow conditions, spheres and short filomicelles are taken up by cells more readily than longer filaments because the latter are extended by the flow. Preliminary results further demonstrate that filomicelles can effectively deliver the anticancer drug paclitaxel and shrink human-derived tumours in mice. Although these findings show that long-circulating vehicles need not be nanospheres, they also lend insight into possible shape effects of natural filamentous viruses.
NanoBioPolymers and Molecular & Cell Biophysics Lab, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Pharmaceutics, Rutgers University, Piscataway, New Jersey 08854, USA These authors contributed equally to this work.
