生物谷報(bào)道：大多數(shù)多藥物抗藥性機(jī)理（對(duì)抗生素,、抗菌劑,、抗瘧疾藥物,、殺蟲(chóng)劑,、還有對(duì)人類的癌癥化療藥物等多種藥物的抗藥性）涉及一種能夠?qū)⑺幬锍槌黾?xì)胞的轉(zhuǎn)運(yùn)蛋白,。研究人員對(duì)這種轉(zhuǎn)運(yùn)蛋白的原型分子—哺乳動(dòng)物P-糖蛋白—幾十年來(lái)已經(jīng)做了大量研究,，但只是在過(guò)去幾年里才獲得了充分的結(jié)構(gòu)和生化數(shù)據(jù)，使我們能夠從機(jī)理上對(duì)其有一個(gè)認(rèn)識(shí),。在最新的一期《Nature》雜志上,，Chris Higgins對(duì)我們當(dāng)前關(guān)于4大類多藥物轉(zhuǎn)運(yùn)蛋白的知識(shí)進(jìn)行了綜述。這4類轉(zhuǎn)運(yùn)蛋白之間的不同之處和相似之處正在為了解多藥物抗藥性是怎樣實(shí)現(xiàn)的提供新的線索,。這項(xiàng)工作尚未解決緊迫的臨床問(wèn)題,，但也許能夠?yàn)橹贫ǚ乐够蚶@過(guò)多藥物抗藥性的策略鋪平道路。

FIGURE 1. Substrates of multidrug transporters.

Multidrug transporters have subtly different multispecificities. However, their substrates share a number of features in common: planar, heterocyclic, lipophilic compounds of molecular mass less than 800 Da and, often, weakly cationic.

原文出處：

Nature   Volume 446 Number 7137

Multiple molecular mechanisms for multidrug resistance transporters p749
Christopher F. Higgins

doi:10.1038/nature05630

First paragraph | Full Text | PDF (1,309K)

See also: Editor's summary

 作者簡(jiǎn)介：

Professor Christopher F Higgins
Director CSC and Head of Division
Division of Clinical Sciences

Working in research themes:

Cancer