生物谷報(bào)道：來自Alabama大學(xué)Birmingham分校（UAB）的科學(xué)家最近發(fā)現(xiàn),，紅酒中的物質(zhì)可以減少患前列腺癌的風(fēng)險(xiǎn)。
科學(xué)家在研究中讓雄性老鼠攝入紅酒中的植物成分——白藜蘆醇（resveratrol）,，這是一種有抗氧化和抗癌作用的物質(zhì),。其它含有該物質(zhì)的食物包括葡萄、覆盆子,、花生和藍(lán)莓等,。結(jié)果顯示老鼠患前列腺癌的風(fēng)險(xiǎn)降低了87%，并且這種抗癌效果在食用含摻有粉狀白藜蘆醇食物后7個(gè)月最佳,。
而其它患上了癥狀較輕的前列腺癌的老鼠中,，48%的腫瘤生長(zhǎng)速度相比未服用白藜蘆醇的老鼠有所停止或放緩。
此項(xiàng)研究發(fā)表在《腫瘤雜志》（Journal of Carcinogenesis）的8月在線版上,。
研究主要負(fù)責(zé)人,，UAB藥理和毒物學(xué)博士Coral Lamartiniere認(rèn)為，研究結(jié)果再次證實(shí)紅酒中的白藜蘆醇除了對(duì)心臟健康有好處外,，還擁有強(qiáng)大的化學(xué)防癌作用,。在2006年5月發(fā)表于同一刊物的文章中，UAB小組曾發(fā)現(xiàn)白藜蘆醇能降低雌性老鼠乳腺癌風(fēng)險(xiǎn),。
Lamartiniere表示他的研究小組對(duì)于紅酒和漿果中類似白藜蘆醇的多酚物質(zhì)強(qiáng)大的化學(xué)抗癌作用感到很驚喜,。Lamartiniere和其他科學(xué)家表示他們正在著手測(cè)試人類白藜蘆醇的攝入量，以確定多大濃度能帶來防癌效果,。UAB小組在老鼠實(shí)驗(yàn)中使用的量相當(dāng)于一人每天喝一瓶紅酒,，這無疑太多。醫(yī)生通常建議適度飲用紅酒：男性平均每天2杯,，女性1杯,。 （教育部科技發(fā)展中心）
原文鏈接：http://www.physorg.com/news107785087.html
原始出處:
Journal of Carcinogenesis 2007, 6:3 doi:10.1186/1477-3163-6-3
Published 16 March 2007
Genistein chemoprevention of prostate cancer in TRAMP mice
Jun Wang1 , Isam-Eldin Eltoum2 ,3 and Coral A Lamartiniere1 ,3
1Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA
2Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
3Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA
Abstract
Epidemiological studies suggest an inverse association between soy intake and prostate cancer risk. Genistein, the predominant phytoestrogen in soy food, has been proposed as a potential chemopreventive agent due to its anti-estrogen and tyrosine kinase inhibitory effects. To determine the most effective period for genistein chemoprevention, the Transgenic adenocarcinoma mouse prostate (TRAMP) model was used. The treatments were 250 mg genistein/kg AIN-76A diet 1) prepubertally only, 2) in adulthood only or 3) through out life. Controls received AIN-76A diet. By 28 weeks of age, 100% TRAMP mice fed control diet developed prostatic intraepithelial neoplasia (PIN) or adenocarcinomas with 6%, 16%, 44% and 34% developing high grade PIN, well differentiated, moderately differentiated and poorly differentiated prostatic adenocarcinomas, respectively. Prepubertal only (1–35 days postpartum) and adult only genistein treatments (12 – 28 weeks) resulted in 6% and 29% decreases in poorly-differentiated cancerous lesions compared with controls, respectively. The most significant effect was seen in the TRAMP mice exposed to genistein throughout life (1–28 weeks) with a 50% decrease in poorly-differentiated cancerous lesions. In a separate experiment in castrated TRAMP mice, dietary genistein suppressed the development of advanced prostate cancer by 35% compared with controls. Of the tumors that developed in castrated TRAMP mice, 100% were poorly-differentiated in contrast to the 37% of noncastrated TRAMP mice that developed poorly-differentiated tumors. ICI 182,780 (ICI), genistein and estrogen down-regulated androgen receptor (AR), estrogen receptor alpha (ER-α) and progesterone receptor (PR) in the prostates of C57BL/6 mice, and act independently of ER. Our data obtained in intact and castrated transgenic mice suggest that genistein may be a promising chemopreventive agent against androgen-dependent and independent prostate cancers.
