MicroRNA已知通過與一個(gè)目標(biāo)信使RNA（mRNA）中的不完全互補(bǔ)序列相互作用來(lái)調(diào)控基因表達(dá),。但真實(shí)情況是否相反呢,？即mRNA表達(dá)是否會(huì)影響微RNA的分布呢？一項(xiàng)新的研究表明，一個(gè)假基因（腫瘤抑制因子假基因PTENP1）的3'未翻譯區(qū)域(UTR)能與相關(guān)的蛋白編碼基因PTEN結(jié)合相同的微RNA,。
這表明,，假基因具有一個(gè)作為“誘餌”的生物功能：螯合MicroRNA，從而影響它們對(duì)所表達(dá)的基因的調(diào)控,。（生物谷Bioon.net）
生物谷推薦最新腫瘤會(huì)議：第一屆上海腫瘤基礎(chǔ)和轉(zhuǎn)化醫(yī)學(xué)前沿研討會(huì),，2010
http://www.canceraisa.com/
生物谷推薦原文出處：
Nature doi:10.1038/nature09144
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Laura Poliseno,Leonardo Salmena,Jiangwen Zhang,Brett Carver,William J. Haveman& Pier Paolo Pandolfi
The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on their ability to compete for microRNA binding, independently of their protein-coding function. As a model for the protein-coding-independent role of RNAs, we describe the functional relationship between the mRNAs produced by the PTEN tumour suppressor gene and its pseudogene PTENP1 and the critical consequences of this interaction. We find that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role. We also show that the PTENP1 locus is selectively lost in human cancer. We extended our analysis to other cancer-related genes that possess pseudogenes, such as oncogenic KRAS. We also demonstrate that the transcripts of protein-coding genes such as PTEN are biologically active. These findings attribute a novel biological role to expressed pseudogenes, as they can regulate coding gene expression, and reveal a non-coding function for mRNAs.
