一個(gè)由多國(guó)研究人員組成的小組最新發(fā)現(xiàn),，人體內(nèi)一個(gè)與免疫系統(tǒng)有關(guān)的基因可能在帕金森氏癥病情發(fā)展過(guò)程中扮演著重要角色,。這一發(fā)現(xiàn)為探索人體免疫系統(tǒng)與帕金森氏癥之間的關(guān)系提供了新依據(jù)。
美國(guó)紐約州沃茲沃斯中心等機(jī)構(gòu)研究人員對(duì)2000多名帕金森氏癥患者和2000名健康人員進(jìn)行研究。他們發(fā)現(xiàn)，人體白細(xì)胞抗原—DR區(qū)域內(nèi)有一個(gè)基因變異與帕金森氏癥密切相關(guān)。人體白細(xì)胞抗原—DR區(qū)域內(nèi)包含大量與人類免疫系統(tǒng)相關(guān)的基因,。
研究小組成員、美國(guó)華盛頓大學(xué)副教授賽勒斯·扎貝蒂昂說(shuō)：“這意味著免疫系統(tǒng)可能在帕金森氏癥病情發(fā)展過(guò)程中起重要作用,，這是我們迄今發(fā)現(xiàn)的最好證據(jù),。”但目前研究人員尚無(wú)法具體確定這個(gè)基因。
這項(xiàng)研究成果發(fā)表在新一期英國(guó)《自然·遺傳學(xué)》（Nature Genetics）雜志網(wǎng)絡(luò)版上,。（生物谷Bioon.com）
生物谷推薦原文出處：
Nature Genetics doi:10.1038/ng.642
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Taye H Hamza1, Cyrus P Zabetian2,3, Albert Tenesa4, Alain Laederach1, Jennifer Montimurro1, Dora Yearout1,2,3, Denise M Kay1, Kimberly F Doheny5, Justin Paschall6, Elizabeth Pugh5, Victoria I Kusel1, Randall Collura1, John Roberts7, Alida Griffith8, Ali Samii2,3, William K Scott9, John Nutt10, Stewart A Factor11 & Haydeh Payami1
Parkinson's disease is a common disorder that leads to motor and cognitive disability. We performed a genome-wide association study of 2,000 individuals with Parkinson's disease (cases) and 1,986 unaffected controls from the NeuroGenetics Research Consortium (NGRC)1, 2, 3, 4, 5. We confirmed associations with SNCA2, 6, 7, 8 and MAPT3, 7, 8, 9, replicated an association with GAK9 (using data from the NGRC and a previous study9, P = 3.2 × 10?9) and detected a new association with the HLA region (using data from the NGRC only, P = 2.9 × 10-8), which replicated in two datasets (meta-analysis P = 1.9 × 10?10). The HLA association was uniform across all genetic and environmental risk strata and was strong in sporadic (P = 5.5 × 10?10) and late-onset (P = 2.4 × 10?8) disease. The association peak we found was at rs3129882, a noncoding variant in HLA-DRA. Two studies have previously suggested that rs3129882 influences expression of HLA-DR and HLA-DQ10, 11. The brains of individuals with Parkinson's disease show upregulation of DR antigens and the presence of DR-positive reactive microglia12, and nonsteroidal anti-inflammatory drugs reduce Parkinson's disease risk4, 13. The genetic association with HLA supports the involvement of the immune system in Parkinson's disease and offers new targets for drug development.
