感染性細(xì)菌的藥物抗性日漸增加，迫使科學(xué)家們發(fā)明新方法來(lái)對(duì)付這些有害細(xì)菌。現(xiàn)在,，通過(guò)將現(xiàn)有抗生素與非抗生素藥物混合使用,，研究人員發(fā)現(xiàn)了一種重新使用抗生素藥物的新方法，新成果發(fā)表在4月在線出版的《自然—化學(xué)生物學(xué)》期刊上,。
Eric Brown,、Gerard Wright和同事合作，將治療帕金森氏癥,、癌癥,、炎癥和其他疾病的藥物與抗生素共同使用，試圖尋找混合藥物比單個(gè)藥物效果更好的病例,。他們鑒別出非抗生素藥物能弱化細(xì)菌細(xì)胞的幾種病例,，從而讓現(xiàn)有的抗生素能殺死這些細(xì)菌。洛派丁胺是一種治療腹瀉的藥物,，他們特別指出,，通過(guò)干涉正常的細(xì)胞膜功能，洛派丁胺能讓細(xì)菌細(xì)胞對(duì)各種四環(huán)素類抗生素產(chǎn)生敏感性,，這是一個(gè)意外發(fā)現(xiàn),。（生物谷Bioon.com）
生物谷推薦原文：
Nature Chemical Biology DOI:10.1038/nchembio.559
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
Linda Ejim; Maya A Farha; Shannon B Falconer; Jan Wildenhain; Brian K Coombes; Mike Tyers; Eric D Brown; Gerard D Wright
Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug–resistant isolates.
