最近，瑞士洛桑大學(xué)醫(yī)院的David Baud等在美國(guó)疾病控制與預(yù)防中心（CDC）的《新發(fā)感染性疾病》雜志Emerg Infect Dis發(fā)表論文"Role of Chlamydia trachomatis in Miscarriage"證實(shí)流產(chǎn)與血清學(xué)/分子學(xué)顯示的存在沙眼衣原體感染相關(guān)聯(lián),，這項(xiàng)研究成果支持了沙眼衣原體感染在流產(chǎn)中的作用,。
為確定沙眼衣原體在流產(chǎn)中的作用，研究人員前瞻性收集了386名流產(chǎn)或未流產(chǎn)婦女的血清,、宮頸拭子標(biāo)本和胎盤(pán)樣本,。
結(jié)果：流產(chǎn)組中的抗沙眼衣原體免疫球蛋白G流行率較對(duì)照組高(15.2%對(duì)7.3%，P = 0.018),。對(duì)年齡,、出生、受教育情況和性伴侶數(shù)校正后，沙眼衣原體血清學(xué)陽(yáng)性結(jié)果與流產(chǎn)的關(guān)系依然顯著【比值比(OR)：2.3】,。流產(chǎn)婦女的妊娠產(chǎn)物或胎盤(pán)中沙眼衣原體DNA被擴(kuò)增情況較對(duì)照組頻繁(4%對(duì)0.7%;P = 0.026),。免疫組化分析證實(shí)，7例聚合酶鏈反應(yīng)(PCR)結(jié)果陽(yáng)性的患者中5例患者的胎盤(pán)感染了沙眼衣原體,，而在全8例陰性對(duì)照檢測(cè)者的胎盤(pán)樣本中免疫組化分析結(jié)果均為陰性,。（生物谷Bioon.com）
doi:10.3201/eid1709.100865
PMC:
PMID:
Role of Chlamydia trachomatis in Miscarriage
David Baud, Genevieve Goy, Katia Jaton, Maria-Chiara Osterheld, Serafin Blumer, Nicole Borel, Yvan Vial, Patrick Hohlfeld, Andreas Pospischil, and Gilbert Greub
To determine the role of Chlamydia trachomatis in miscarriage, we prospectively collected serum, cervicovaginal swab specimens, and placental samples from 386 women with and without miscarriage. Prevalence of immunoglobulin G against C. trachomatis was higher in the miscarriage group than in the control group (15.2% vs. 7.3%; p = 0.018). Association between C. trachomatis–positive serologic results and miscarriage remained significant after adjustment for age, origin, education, and number of sex partners (odds ratio 2.3, 95% confidence interval 1.1–4.9). C. trachomatis DNA was more frequently amplified from products of conception or placenta from women who had a miscarriage (4%) than from controls (0.7%; p = 0.026). Immunohistochemical analysis confirmed C. trachomatis in placenta from 5 of 7 patients with positive PCR results, whereas results of immunohistochemical analysis were negative in placenta samples from all 8 negative controls tested. Associations between miscarriage and serologic/molecular evidence of C. trachomatis infection support its role in miscarriage.
