英國(guó)研究人員最近宣布，利用不同種類干細(xì)胞培育出的“人造骨骼”有不同性質(zhì),，他們已探明多種“人造骨骼”的不同性質(zhì),，這一成果將有利于提高骨骼移植的成功率。
英國(guó)帝國(guó)理工學(xué)院的研究人員在新一期《自然·材料》雜志上報(bào)告說(shuō),，科學(xué)界已能利用多種干細(xì)胞培育出類似骨骼的物質(zhì),，但是這些“人造骨骼”在性質(zhì)上具有較大區(qū)別。
借助激光光譜儀和電子顯微鏡等設(shè)備,，研究人員發(fā)現(xiàn),，利用實(shí)驗(yàn)鼠骨髓干細(xì)胞和頭骨干細(xì)胞培育出的“人造骨骼”在硬度等方面最接近真實(shí)骨骼的性質(zhì),。但利用實(shí)驗(yàn)鼠胚胎干細(xì)胞培育出的“人造骨骼”的硬度就要小很多，并且在化學(xué)成分上也相對(duì)更為簡(jiǎn)單,。
研究人員說(shuō),，許多病人需要移植骨骼，如果能選擇與移植部位原有骨骼性質(zhì)最為相似的“人造骨骼”,，那么移植成功的可能性就會(huì)大很多,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Materials 26 July 2009 | doi:10.1038/nmat2505
Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation
Eileen Gentleman1,2, Robin J. Swain1, Nicholas D. Evans1,2, Suwimon Boonrungsiman1,2, Gavin Jell1,2, Michael D. Ball1,2, Tamaryn A. V. Shean3, Michelle L. Oyen3, Alexandra Porter1 & Molly M. Stevens1,2
An important aim of regenerative medicine is to restore tissue function with implantable, laboratory-grown constructs that contain tissue-specific cells that replicate the function of their counterparts in the healthy native tissue. It remains unclear, however, whether cells used in bone regeneration applications produce a material that mimics the structural and compositional complexity of native bone. By applying multivariate analysis techniques to micro-Raman spectra of mineralized nodules formed in vitro, we reveal cell-source-dependent differences in interactions between multiple bone-like mineral environments. Although osteoblasts and adult stem cells exhibited bone-specific biological activities and created a material with many of the hallmarks of native bone, the 'bone nodules' formed from embryonic stem cells were an order of magnitude less stiff, and lacked the distinctive nanolevel architecture and complex biomolecular and mineral composition noted in the native tissue. Understanding the biological mechanisms of bone formation in vitro that contribute to cell-source-specific materials differences may facilitate the development of clinically successful engineered bone.
1 Department of Materials, Imperial College London, London SW7 2AZ, UK
2 Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK
3 Cambridge University Engineering Department, Cambridge CB2 1PZ, UK
