據(jù)國外媒體5日報道,，美國科學(xué)家稱，由于西蘭花含有的一種化合物可以鎖定腫瘤干細胞,，這種蔬菜或掌握著預(yù)防甚至治療乳腺癌的“鑰匙”。
西蘭花堪稱蔬菜類中的“超級食品”,，含有很高的蘿卜硫素,，這種化合物能消滅腫瘤干細胞，阻止病情進一步惡化,。美國密歇根大學(xué)綜合腫瘤治療中心科學(xué)家在實驗室對老鼠和培養(yǎng)細胞的相關(guān)測試取得了成功,。
領(lǐng)導(dǎo)實施這項研究的孫杜欣(音譯)教授說：“研究人員以前就一直在研究蘿卜硫素對癌癥的影響，而最新研究表明其益處在于抑制乳腺癌‘腫瘤干細胞’的生長,。這種新證據(jù)表明,，蘿卜硫素或西蘭花萃取液通過鎖定腫瘤干細胞,，從而具有預(yù)防或治療癌癥的潛力。”研究結(jié)果刊登在最新一期的《臨床癌癥研究》雜志上,。
研究人員表示,，當前的化學(xué)療法對腫瘤干細胞并不奏效,，這也是乳腺癌總愛復(fù)發(fā)和擴散的原因,。他們認為,，消除腫瘤干細胞是控制腫瘤生長的關(guān)鍵,。在最新研究中,，研究人員給患有乳腺癌的老鼠體內(nèi)注射了從西蘭花萃取液中提取的不同濃度的蘿卜硫素,。
由于西蘭花吃起來口感不佳，許多人并不喜歡,，包括美國前總統(tǒng)喬治- W-布什。但這種蔬菜的健康功效已經(jīng)得到普遍承認，多項研究顯示,，西蘭花含有的一種化合物可增強細胞中DNA的修復(fù)能力,。還有證據(jù)表明這種化合物能令動脈保持健康,，或能修復(fù)糖尿病對心臟血管造成的損傷,。此外，西蘭花富含維生素C和纖維質(zhì),，而一棵西蘭花所含的維生素K量幾乎是醫(yī)生建議成年人每日攝入維生素K 量的兩倍,。（生物谷Bioon.com）
生物谷推薦原文出處：
Clinical Cancer Research, doi: 10.1158/1078-0432.CCR-09-2937
Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
Yanyan Li1,3, Tao Zhang1, Hasan Korkaya2, Suling Liu2, Hsiu-Fang Lee1, Bryan Newman1, Yanke Yu1, Shawn G. Clouthier2, Steven J. Schwartz3, Max S. Wicha2, and Duxin Sun1
Corresponding Authors:
Duxin Sun, Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Room 2020, Ann Arbor, MI 48109. Phone: 734-615-8740; Fax: 734-615-6162; E-mail: [email protected], Max S. Wicha, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Room 6302, Ann Arbor, MI 48109. Phone: 734-936-1831; Fax: 734-615-3947; E-mail: [email protected], and Steven J. Schwartz, Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Ct., 235 Parker Food Science & Technology Building, Columbus, OH 43210. Phone: 614-292-2934;
Purpose: The existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention. In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism.
Experimental Design: Aldefluor assay and mammosphere formation assay were used to evaluate the effect of sulforaphane on breast CSCs in vitro. A nonobese diabetic/severe combined immunodeficient xenograft model was used to determine whether sulforaphane could target breast CSCs in vivo, as assessed by Aldefluor assay, and tumor growth upon cell reimplantation in secondary mice. The potential mechanism was investigated using Western blotting analysis and β-catenin reporter assay.
Results: Sulforaphane (1-5 μmol/L) decreased aldehyde dehydrogenase–positive cell population by 65% to 80% in human breast cancer cells (P < 0.01) and reduced the size and number of primary mammospheres by 8- to 125-fold and 45% to 75% (P < 0.01), respectively. Daily injection with 50 mg/kg sulforaphane for 2 weeks reduced aldehyde dehydrogenase–positive cells by >50% in nonobese diabetic/severe combined immunodeficient xenograft tumors (P = 0.003). Sulforaphane eliminated breast CSCs in vivo, thereby abrogating tumor growth after the reimplantation of primary tumor cells into the secondary mice (P < 0.01). Western blotting analysis and β-catenin reporter assay showed that sulforaphane downregulated the Wnt/β-catenin self-renewal pathway
