過去有研究顯示,，肥胖女性更容易罹患與雌激素過多有關的乳腺癌,。美國一項最新研究則進一步發(fā)現(xiàn),，過度肥胖的絕經(jīng)女性罹患三陰乳腺癌風險也相對較高。
上述結果是美國西雅圖弗雷德·哈欽森癌癥研究中心分析了逾15.5萬名絕經(jīng)女性的健康數(shù)據(jù)后發(fā)現(xiàn)的,。這些研究對象的年齡在50歲至79歲之間,，其中2610人患有與雌激素過多有關的乳腺癌，307名患有三陰乳腺癌,。研究人員經(jīng)對比其身體質量指數(shù)后發(fā)現(xiàn),，與體重正常人群相比，肥胖女性患三陰乳腺癌的風險高35％,，患其他類型乳腺癌的風險高39％,。
研究項目負責人阿曼達·菲普斯說，多數(shù)絕經(jīng)女性的雌激素來自脂肪組織,，人越胖,，雌激素越多，所以過度肥胖的絕經(jīng)女性患某些乳腺癌的幾率相對較大,。但與其他一些乳腺癌不同,，三陰乳腺癌不受雌激素影響，所以過去有關這類癌癥的研究忽視了身體肥胖因素,。
這項研究成果已發(fā)表在最新一期美國《癌癥流行病學,、生物標志與預防》雜志上。（生物谷Bioon.com）
生物谷推薦原文出處：
Cancer Epidemiology, Biomarkers & Prevention doi: 10.1158/1055-9965.EPI-10-0974
Body Size, Physical Activity, and Risk of Triple-Negative and Estrogen Receptor–Positive Breast Cancer
Amanda I. Phipps1, Rowan T. Chlebowski2, Ross Prentice1, Anne McTiernan1, Marcia L. Stefanick3, Jean Wactawski-Wende4, Lewis H. Kuller5, Lucile L. Adams-Campbell6, Dorothy Lane7, Mara Vitolins8, Geoffrey C. Kabat9, Thomas E. Rohan9 and Christopher I. Li1
Abstract
Background: Triple-negative breast cancer, characterized by a lack of hormone receptor and HER2 expression, is associated with a particularly poor prognosis. Focusing on potentially modifiable breast cancer risk factors, we examined the relationship between body size, physical activity, and triple-negative disease risk.
Methods: Using data from 155,723 women enrolled in the Women's Health Initiative (median follow-up, 7.9 years), we assessed associations between baseline body mass index (BMI), BMI in earlier adulthood, waist and hip circumference, waist–hip ratio, recreational physical activity, and risk of triple-negative (n = 307) and estrogen receptor–positive (ER+, n = 2,610) breast cancers.
Results: Women in the highest versus lowest BMI quartile had 1.35-fold (95% CI, 0.92–1.99) and 1.39-fold (95% CI, 1.22–1.58) increased risks of triple-negative and ER+ breast cancers, respectively. Waist and hip circumferences were positively associated with risk of ER+ breast cancer (Ptrend = 0.01 for both measures) but were not associated with triple-negative breast cancer. Compared with women who reported no recreational physical activity, women in the highest activity tertile had similarly lower risks of triple-negative and ER+ breast cancers (HR = 0.77; 95% CI, 0.51–1.13; and HR = 0.85; 95% CI, 0.74–0.98, respectively).
Conclusions: Despite biological and clinical differences, triple-negative and ER+ breast cancers are similarly associated with BMI and recreational physical activity in postmenopausal women. The biological mechanisms underlying these similarities are uncertain and these modest associations require further investigation.
