生物谷報(bào)道：機(jī)體生成心臟、腸等非對(duì)稱臟器時(shí)依靠什么區(qū)分左右呢,？日本科學(xué)家在最新一期Nature雜志上發(fā)表論文說(shuō),，他們找到了決定這類臟器分化方向的兩個(gè)基因。這期Nature共發(fā)表了兩篇相關(guān)的文章,。
日本東京理科大學(xué)教授松野健治帶領(lǐng)的研究小組利用果蠅進(jìn)行實(shí)驗(yàn),，發(fā)現(xiàn)“Myo31DF”和“Myo61F”兩個(gè)基因在果蠅臟器分化方向的決定過(guò)程中起著關(guān)鍵作用。
研究人員從約6000只果蠅中篩選出腸的方向左右顛倒的個(gè)體,，然后比較它們體內(nèi)各基因與正常果蠅的基因有何差異,。分析結(jié)果顯示，若基因“Myo31DF”不發(fā)揮作用,，果蠅腸的方向就會(huì)顛倒,，而與這個(gè)基因相似的“Myo61F”基因如果作用過(guò)頭也會(huì)出現(xiàn)相同結(jié)果。研究人員由此確認(rèn),，肌體內(nèi)非對(duì)稱臟器的正常形成必須依靠上述兩個(gè)基因協(xié)調(diào),，恰到好處地發(fā)揮作用。
松野教授認(rèn)為,，這兩個(gè)基因控制著臟器形成時(shí)細(xì)胞的移動(dòng)方式,。這項(xiàng)研究為再生醫(yī)療領(lǐng)域人工模擬臟器的復(fù)雜構(gòu)造提供了技術(shù)基礎(chǔ)。
生物谷專家認(rèn)為,，有關(guān)器官的不對(duì)稱研究一直是科學(xué)研究中的熱門(mén)領(lǐng)域,，這兩個(gè)新基因的發(fā)現(xiàn)，使人們對(duì)器官早期方向性的發(fā)育中有全新的認(rèn)識(shí),。這一研究也將促進(jìn)更高等生物的器官發(fā)育的機(jī)制研究,。
拓展閱讀:
1 器官不對(duì)稱的發(fā)育研究
·不對(duì)稱性的發(fā)育之謎
·細(xì)胞不對(duì)稱性分裂與成層現(xiàn)象
·Cell：胚胎左右發(fā)育研究的重大進(jìn)展
·《Science》：心臟為何長(zhǎng)在左邊？
·不對(duì)稱器官與小RNA指導(dǎo)的DNA修飾
·Sonic Hedgehog (Shh)-參與臟器左右不對(duì)稱
·人類器官分布有新解：基因決定內(nèi)臟位置
·細(xì)胞外鈣是決定脊椎動(dòng)物器官左右不對(duì)稱的感受器
·肢體不對(duì)稱發(fā)育中Hox基因扮演雙重角色
·人類器官分布有新解：基因決定五臟六腑位置
2 器官不對(duì)稱的美學(xué)研究
·醫(yī)學(xué)研究發(fā)現(xiàn):人體器官不對(duì)稱的美學(xué)秘密
3 神經(jīng)系統(tǒng)不對(duì)稱的研究
·神經(jīng)系統(tǒng)細(xì)胞不對(duì)稱發(fā)育分化的機(jī)理被揭示
·神經(jīng)系統(tǒng)發(fā)育期細(xì)胞不對(duì)稱分裂機(jī)制
·Nature：中國(guó)人大腦有獨(dú)特的語(yǔ)言區(qū)
·大腦兩半球機(jī)能不對(duì)稱性與精神病理學(xué)的關(guān)系
·正常人,、裂腦人和半腦人的大腦兩半球機(jī)能不對(duì)稱性
·大腦兩半球機(jī)能的不對(duì)稱性
原始出處:
Speder P, Adam G, Noselli S. Type ID unconventional myosin controls left-right asymmetry in Drosophila.
Nature. 2006 Apr 6;440(7085):803-7.
Hozumi S, Maeda R, Taniguchi K, Kanai M, Shirakabe S, Sasamura T, Speder P, Noselli S, Aigaki T, Murakami R, Matsuno K. An unconventional myosin in Drosophila reverses the default handedness in visceral organs. Nature. 2006 Apr 6;440(7085):798-802.
作者介紹
Noselli S. 發(fā)表的重要文章
Spéder*, P., Adam*, G. & Noselli, S. (2006). Type ID unconventional myosin controls left-right asymmetry in Drosophila. Nature, 440:803-807. (*, co-first authors) [Abstract]
Comment in : The Scientist [Link] -- CNRS News [Link] --
Hozumi, S., Maeda, R., Taniguchi, K., Sasamura, T., Spéder, P., Noselli, S., Aigaki, T., Murakami, R., Matsuno, K. (2006). An unconventional myosin in Drosophila reverses the default handedness in visceral organs. Nature, 440:798-802. [Abstract]
Colombani*, J., Bianchini*, L., Layalle*, S., Pondeville, E., Dauphin-Villemant, C., Antoniewski, C., Carre, C., Noselli, S., and Léopold, P. (2005). Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science, 310:667-670. (*, co-first authors) [PDF-386Ko]
Comment in: Science 2005, 310:630-631 -- Current Biology 2005, 15:R825-827.
Medioni C. and Noselli S. (2005). Dynamics of the basement membrane in invasive epithelial clusters in Drosophila. Development, 132:3069-77. [PDF-1080Ko].
Comment in : Development 2005, 132:1303e -- Nature Reviews|Molecular Cell Biology August 2005, 6:
8, p.595. [PDF-249Ko].
Adam G, Gausz J, Noselli S, Kurucz E, Ando I, Udvardy A. (2004). Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster. Mech. Dev.GEP. (3):329-33. [PDF-253Ko].
Rousset, R., Almeida, L. and Noselli, S. (2003). Equations de la soudure épithéliale. Med Sci (Paris). 19, :785-7. (Article in French) [PDF-141Ko]
Rousset, R., Almeida, L. and Noselli, S. (2003). Drosophila Morphogenesis : The Newtonian Revolution. Current Biology, 13, R494-R495. [PDF-123Ko]
Ghiglione, C., Amundadottir, L., Andresdottir, M., Bilder, D., Diamonti, JA., Noselli, S., Perrimon, N. and Carraway, KL. (2003). Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1. Development,130, 4483-4493. [PDF-399Ko]
Adam, G., Perrimon, N. and Noselli, S. (2003). The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila. Development, 130, 2397-2406. [PDF-403Ko]
Noselli, S. (2002). Drosophila, actin and videotape - New insights in wound healing. Nature Cell Biology, 4, E251-E253. [PDF-412Ko]
Ghiglione, C.*, Devergne, O.*, Georgenthum, E., Carballès, F., Medioni, C., Cerezo, D. and Noselli, S. (2002). The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis. Development, 129, 5437-5447. [PDF-761Ko] (*, co-first authors)
LLano*, E., Adam*, G. Pendas, AM., Quesada, V., Sanchez, LM., Santamaria, I., Noselli, S., Lopez-Otin, C. (2002). Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression. J. Biol. Chem., 277, 23321-23329. [PDF-642Ko] (*, co-first authors)
Bourbon, H. M, Gonzy-Treboul G., Peronnet F., Alin M. F., Ardourel C., Benassayag C., Cribbs D., Deutsch J., Ferrer P., Haenlin M., Lepesant J. A., Noselli S., Vincent A. (2002). A P-insertion screen identifying novel X-linked essential genes in Drosophila. , Mech. Dev., 110, 71-83. [PDF-320Ko]
Ghiglione, C., Bach, E. A., Paraiso, Y., Carraway III, K. L., Noselli, S., Perrimon, N. (2002). Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development, 129, 175-186. [PDF-307Ko]
Suzanne, M., Perrimon N., & Noselli, S. (2001). The Drosophila JNK pathway controls the morphogenesis of the egg dorsal appendages and micropyle. Developmental Biology, 237, 282-294. [PDF-2,100Ko]
Noselli S. & Perrimon N. (2000). Are there close encounters between signaling pathways? Science, 290, 68-69. [PDF-153Ko]
Agnès, F., Suzanne, M, and Noselli, S. (1999). The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis. Development, 126, 5453-5462. [PDF-337Ko]
Noselli, S., and Agnès, F. (1999). Roles of the JNK signaling pathway in Drosophila morphogenesis. Cur. Opi. Gen. Dev., 9, 466-472. [PDF-330Ko]
Suzanne, M., Irie, K., Glise, B., Agnès, F., Mori, E., Matsumoto, K., and Noselli, S. (1999). The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development. Genes & Dev., 13, 1464-1474. [PDF-2,964Ko]
Agnès F. and Noselli S. (1999). Dorsal closure in Drosophila: a genetic model for wound-healing? C. R. Acad. Sci. Paris, 322, 5-13.
Noselli, S. (1998). JNK signaling and morphogenesis in Drosophila. Trends in Genetics, 14, 33-38. [PDF-812Ko]
Holland, P. M., Suzanne, M., Campbell, J. S., Noselli, S., and Cooper, J. A. (1997). MKK7 is a stress activated MAP kinase kinase functionally related to hemipterous. J. Biol. Chem., 272, 24994-24998. [PDF-427Ko]
Glise, B., and Noselli, S. (1997). Coupling of JNK and DPP signaling pathways in Drosophila morphogenesis. Genes & Dev., 11, 1738-1747. [Abstract]
Glise, B., Bourbon, H., and Noselli, S. (1995). hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83, 451-461.
Brand S., Pichoff S., Noselli S., Bourbon H.M. (1995). Novel Drosophila melanogaster genes encoding RRM-type RNA-binding protein identified by a degenerate PCR strategy. Gene 154, 187-192.
Noselli, S. and Vincent, A. (1992). The Drosophila melanogaster ribosomal protein L17A-encoding gene. Gene 118, 273-278.
Noselli, S., Payre, F., and Vincent, A. (1992). Zinc fingers and other domains cooperate in binding of Drosophila sry b and d proteins at specific chromosomal sites. Mol. Cell. Biol. 12, 724-733.
Noselli, S., and Vincent, A. (1991). A Drosophila nulear localization signal included in a 18 amino-acid fragment from the sry d zinc finger protein. FEBS Letters 280, 167-170.
Payre, F., Noselli, S., Lefrere, V., and Vincent, A. (1990). The closely related Drosophila sry b and sry d zinc finger proteins show differential embryonic expression and distincts patterns of binding sites on polytene chromosomes. Development 110, 141-145.
Koichiro Matsuno實(shí)驗(yàn)室
