新一期Nature Genetics發(fā)表最新研究報(bào)告,，解析6個(gè)新發(fā)現(xiàn)的基因,，這6個(gè)新發(fā)現(xiàn)的基因通過影響神經(jīng)中樞控制肥胖。
肥胖屬于非健康狀態(tài),，肥胖不僅影響體型美觀還嚴(yán)重影響健康,，比如說，肥胖者更容易患2型糖尿病和其他慢性代謝疾病,。
研究小組通過全基因組關(guān)聯(lián)分析法對(duì)32000個(gè)人進(jìn)行分析,，篩選出大量的與肥胖相關(guān)的變異，并獲得6個(gè)新的肥胖基因,。這6個(gè)基因分別是：TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2, 和NEGR1,。
基因表達(dá)分析發(fā)現(xiàn)，6個(gè)基因都是在腦細(xì)胞中具有活性,，以前研究發(fā)現(xiàn)的兩個(gè)基因FTO和MC4R也具有相似的特性,。
德國國立基因組研究中心的教授表示，將通過其他的途徑進(jìn)一步研究這6個(gè)基因的功能,。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Genetics 41, 25 - 34 (2008) Published online: 14 December 2008 | doi:10.1038/ng.287
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 10-8): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
