美國斯坦福大學(xué)科學(xué)家7日宣布,，他們發(fā)現(xiàn)了與動脈硬化癥有關(guān)的13個新基因區(qū)，使得與該病有關(guān)的基因區(qū)增加至26個,。
Tim Assimes (left) and Thomas Quertermous
研究人員說,，他們的發(fā)現(xiàn)建立在對14項有關(guān)基因研究數(shù)據(jù)分析的基礎(chǔ)上,，這些數(shù)據(jù)由150多名研究人員從世界各地搜集，包括美國,、冰島,、加拿大和英國等。
動脈硬化癥是造成心臟病的主要風(fēng)險因素之一,。為了解基因?qū)用}硬化癥的影響,，研究人員對歐洲2．2萬名心臟病患者的基因圖譜進行了分析，并將他們的圖譜與6萬名健康人的基因圖譜進行了對比,。在仔細(xì)查對遺傳密碼后,，最終新發(fā)現(xiàn)13個與動脈硬化癥有關(guān)的基因區(qū)。
斯坦福大學(xué)心血管醫(yī)學(xué)教授凱特穆斯在一項新聞公報中說,，新發(fā)現(xiàn)將幫助科學(xué)家找到產(chǎn)生動脈硬化癥的根源,，并研發(fā)出可降低罹患心臟病風(fēng)險的新藥。
研究報告的共同作者,、醫(yī)學(xué)教授阿西邁斯說,，根據(jù)這些信息,，醫(yī)生可以在早期發(fā)現(xiàn)可能患心臟病的高危病人并采取相應(yīng)措施,，如建議病人改變生活方式或?qū)Σ∪诉M行藥物干預(yù)治療，從而降低患心臟病的風(fēng)險,。（生物谷Bioon.com）
Nature Genetics:歐洲,、南亞和中國漢族人群冠心病的易感基因位點
生物谷推薦原文出處：
Nature Genetics, March 6, 2011 DOI: 10.1038/ng.784
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10?8 and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
