英國研究人員日前報告發(fā)現(xiàn)了8個與衰老相關的基因，它們共同控制著人體內(nèi)一種名為DHEAS的類固醇的含量,。
人在20歲左右時,，體內(nèi)DHEAS的含量達到最高峰，然后逐漸衰減,，到85歲時可能只有峰值的5%,。研究顯示，體內(nèi)DHEAS含量不足可能誘發(fā)多種疾病,，如Ⅱ型糖尿病和淋巴瘤等,。
英國倫敦國王學院研究人員在學術刊物《科學公共圖書館—遺傳學》（PLoS Genetics）上報告說,，他們對歐洲和美國約1.5萬人進行了基因組分析,，發(fā)現(xiàn)有8個基因控制著人體內(nèi)的DHEAS含量,。
研究人員說,，這是首個針對DHEAS的大規(guī)?；蜓芯?。下一步的研究重點是尋找調(diào)控這8個基因的方法,，使人體內(nèi)DHEAS含量穩(wěn)定在較高水平,，這或許能幫助人們更加健康長壽,。（生物谷Bioon.com）
生物谷推薦原文出處：
PLoS Genet 7(4): e1002025. doi:10.1371/journal.pgen.1002025
Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms
Guangju Zhai1#, Alexander Teumer2#, Lisette Stolk3,4#, John R. B. Perry5,6#, Liesbeth Vandenput7#, Andrea D. Coviello8#, Annemarie Koster9#, Jordana T. Bell1,6, Shalender Bhasin10, Joel Eriksson7, Anna Eriksson7, Florian Ernst2, Luigi Ferrucci11, Timothy M. Frayling5, Daniel Glass1, Elin Grundberg1,12, Robin Haring13, ?sa K. Hedman6, Albert Hofman4,14, Douglas P. Kiel15, Heyo K. Kroemer16, Yongmei Liu17, Kathryn L. Lunetta18, Marcello Maggio19, Mattias Lorentzon7, Massimo Mangino1, David Melzer5, Iva Miljkovic20, MuTHER Consortium, Alexandra Nica12,21, Brenda W. J. H. Penninx22, Ramachandran S. Vasan8,23, Fernando Rivadeneira3,4, Kerrin S. Small1,12, Nicole Soranzo1,12, André G. Uitterlinden3,4,14, Henry V?lzke24, Scott G. Wilson1,25,26, Li Xi27, Wei Vivian Zhuang18, Tamara B. Harris9?, Joanne M. Murabito8,23?, Claes Ohlsson7?, Anna Murray5?, Frank H. de Jong3?, Tim D. Spector1*, Henri Wallaschofski13?
Abstract
Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands—yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10?36), SULT2A1 (rs2637125; p = 2.61×10?19), ARPC1A (rs740160; p = 1.56×10?16), TRIM4 (rs17277546; p = 4.50×10?11), BMF (rs7181230; p = 5.44×10?11), HHEX (rs2497306; p = 4.64×10?9), BCL2L11 (rs6738028; p = 1.72×10?8), and CYP2C9 (rs2185570; p = 2.29×10?8). These genes are associated with type 2 diabetes, lymphoma, actin filament assembly, drug and xenobiotic metabolism, and zinc finger proteins. Several SNPs were associated with changes in gene expression levels, and the related genes are connected to biological pathways linking DHEAS with ageing. This study provides much needed insight into the function of DHEAS.
