日本研究人員最新發(fā)表的一項(xiàng)報告說,，患十二指腸潰瘍的風(fēng)險與血型有關(guān),，O型血的人患的幾率是其他血型者的1.4倍。
東京大學(xué)醫(yī)學(xué)研究所副教授松田浩一與愛知縣癌癥中心合作,，分析了2003年以來的7072名十二指腸潰瘍患者的資料,，結(jié)果發(fā)現(xiàn)O型血的人患十二指腸潰瘍的人數(shù)是在日本人最多的A型血人的1.43倍。而B型與AB型血的人患十二指腸的幾率基本與A型血相同,。
研究小組在新一期《自然—遺傳學(xué)》雜志上發(fā)表的論文認(rèn)為,，血型是由紅細(xì)胞表面的糖鏈類型決定的，而十二指腸的細(xì)胞內(nèi)也有相同基因制造的糖鏈,，如果是O型血,，導(dǎo)致潰瘍的幽門螺桿菌更容易附著在腸細(xì)胞上面，損害腸粘膜形成潰瘍,。（生物谷Bioon.com）
doi: 10.1038/ng.1109
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A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population
Chizu Tanikawa,Yuji Urabe,Keitaro Matsuo, Michiaki Kubo, Atsushi Takahashi, Hidemi Ito, Kazuo Tajima, Naoyuki Kamatani, Yusuke Nakamura1& Koichi Matsuda.
Through a genome-wide association analysis with a total of 7,035 individuals with duodenal ulcer and 25,323 controls from Japan, we identified two susceptibility loci at the PSCA gene (encoding prostate stem cell antigen) at 8q24 and at the ABO blood group locus at 9q34. The C allele of rs2294008 at PSCA was associated with increased risk of duodenal ulcer (odds ratio (OR) = 1.84; P = 3.92 × 10?33) in a recessive model but was associated with decreased risk of gastric cancer (OR = 0.79; P = 6.79 × 10?12), as reported previously1. The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10?10). Our findings demonstrate a role for genetic variants in the pathogenesis of duodenal ulcer.
