編者按：科學(xué)的探索是建立在興趣基礎(chǔ)上的，這種奇怪的現(xiàn)象很多年前便發(fā)現(xiàn)了，但它的機(jī)理卻一直是謎，今天出版的Science上刊登了這篇文章揭示了其中的機(jī)理,，非常值得參考。也許你不是研究嗅覺的,，但它的思考方式,，idea形成,，思路都值得你思考和借鑒,文章后提供了PDF文件的下載，可以免費(fèi)下載并閱讀,。
Negative Feedback Regulation Ensures the One Receptor-One Olfactory Neuron Rule in Mouse
Shou Serizawa,1,2* Kazunari Miyamichi,1* Hiroko Nakatani,1 Misao Suzuki,4 Michiko Saito,5 Yoshihiro Yoshihara,5 Hitoshi Sakano1,3
Science, Vol. 302, Issue 5653, 2088-2094, December 19, 2003
In the mouse olfactory system, each olfactory sensory neuron (OSN) expresses only one odorant receptor (OR) gene in a monoallelic and mutually exclusive manner. Such expression forms the genetic basis for OR-instructed axonal projection of OSNs to the olfactory bulb of the brain during development. Here, we identify an upstream cis-acting DNA region that activates the OR gene cluster in mouse and allows the expression of only one OR gene within the cluster. Deletion of the coding region of the expressed OR gene or a naturally occurring frame-shift mutation allows a second OR gene to be expressed. We propose that stochastic activation of only one OR gene within the cluster and negative feedback regulation by that OR gene product are necessary to ensure the one receptor–one neuron rule.
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