生物谷： 瑞典Umeå大學的一組科學家發(fā)現(xiàn)了相同信號分子決定眼球和嗅覺細胞形成的獨特機理,。他們的結(jié)果發(fā)表在最新的《發(fā)育細胞雜志》（Developmental Cell）上。
嗅覺和視覺是兩個至關重要的感官系統(tǒng),，使我們有能力感知我們周圍的世界,。目前已經(jīng)確定嗅覺是通過嗅覺黏膜發(fā)展的,，而視覺依靠的是眼球的形成。
嗅覺黏膜和眼球都是在胎兒時期形成的,，但是直到現(xiàn)在人們才精確地知道是什么信號管理著它們的形成,。Umeå大學的研究小組發(fā)現(xiàn)了同樣的信號分子管理著嗅覺細胞和眼球的形成。
這項研究還發(fā)現(xiàn),，短時間暴露在信號下的細胞會變成嗅覺細胞,，而長時間暴露在信號下的細胞會變成眼球的透鏡狀細胞。而通常的機理,，是不同濃度的信號分子會導致形成不同的細胞,。
同樣的信號下，是暴露時間的不同而不是濃度的不同導致形成不同的感覺器官,，這一發(fā)現(xiàn)對于我們理解在胎兒期不同種類的細胞是怎樣形成的有著重要的作用,。 （教育部科技發(fā)展中心）
原文鏈接：http://www.physorg.com/news103451117.html
原始出處:
Developmental Cell, Vol 13, 141-149, 03 July 2007
Short Article
Time of Exposure to BMP Signals Plays a Key Role in the Specification of the Olfactory and Lens Placodes Ex Vivo
My Sjödal,1 Thomas Edlund,1 and Lena Gunhaga1,
1 Umeå Center for Molecular Medicine, Building 6M, 4th floor, Umeå University, S-901 87 Umeå, Sweden
Corresponding author
Lena Gunhaga
[email protected]
Spatial gradients of extracellular signals are implicated in the patterning of many different tissues. Much less is known, however, about how differences in time of exposure of progenitor cells to patterning signals can influence different cell fates. Bone morphogenetic protein (BMP) signals are known to pattern embryonic ectoderm. The olfactory and lens placodes are ectodermal structures of the vertebrate head. By using an explant assay of placodal cell differentiation, we now provide evidence that BMP signals are required and sufficient to induce olfactory and lens placodal cells from progenitor cells located at the anterior neural plate border. We also provide evidence that time of exposure of these progenitor cells to BMP signals plays a key role in the differential specification of olfactory and lens placodal cells.
