英國《BMC生物學(xué)》雜志5日刊登一項最新研究結(jié)果表明,，驅(qū)蚊劑“避蚊胺”（DEET）對中樞神經(jīng)系統(tǒng)中一種關(guān)鍵酶的活性有抑制作用,，研究人員認為有必要重新深入研究這種驅(qū)蚊劑的安全性。
由法國研究人員領(lǐng)導(dǎo)的一個國際小組研究發(fā)現(xiàn),，“避蚊胺”能抑制乙酰膽堿酯酶的活性,，而這種酶在昆蟲和哺乳動物的中樞神經(jīng)系統(tǒng)中都非常關(guān)鍵。
研究人員說,，“避蚊胺”常與其他殺蟲劑混用,，但它在與氨基甲酸鹽類殺蟲劑混用時毒性會增強。研究人員認為,，出于對公眾健康安全的考慮,，應(yīng)該重新對“避蚊胺”的安全性進行深入研究。
“避蚊胺”于20世紀中期被發(fā)明,，化學(xué)名稱為二乙基甲苯酰胺,。它可以有效趨避蚊、蠓,、蚋、蠅和跳蚤等昆蟲，因此在全世界一直得到廣泛使用,。（生物谷Bioon.com）
生物谷推薦原始出處：
BMC Biology 2009, 7:47doi:10.1186/1741-7007-7-47
Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet
Vincent Corbel , Maria Stankiewicz , Cedric Pennetier , Didier Fournier , Jure Stojan , Emmanuelle Girard , Mitko Dimitrov , Jordi Molgo , Jean Marc Hougard and Bruno Lapied
Background
N,N-Diethyl-3-methylbenzamide (deet) remains the gold standard for insect repellents. About 200 million people use it every year and over 8 billion doses have been applied over the past 50 years. Despite the widespread and increased interest in the use of deetin public health programmes, controversies remain concerning both the identification of its target sites at the olfactory system and its mechanism of toxicity in insects, mammals and humans. Here, we investigated the molecular target site for deet and the consequences of its interactions with carbamate insecticides on the cholinergic system.
Results
By using toxicological, biochemical and electrophysiological techniques, we show that deet is not simply a behaviour-modifying chemical but that it also inhibits cholinesterase activity, in both insect and mammalian neuronal preparations. Deet is commonly used in combination with insecticides and we show that deet has the capacity to strengthen the toxicity of carbamates, a class of insecticides known to block acetylcholinesterase.
Conclusion
These findings question the safety of deet, particularly in combination with other chemicals, and they highlight the importance of a multidisciplinary approach to the development of safer insect repellents for use in public health.
