研究人員發(fā)現(xiàn),，睡眠過程中重新出現(xiàn)了與學(xué)習(xí)相關(guān)的神經(jīng)活動模式,，這種重復(fù)活動可能是鞏固記憶的一個重要因素，新成果發(fā)表在日前在線出版的《自然—神經(jīng)科學(xué)》期刊上。這是科學(xué)家們第一次在內(nèi)側(cè)前額葉皮質(zhì)（mPFC）中觀察到這種重復(fù)活動，而且這種活動類似于發(fā)生在大腦海馬區(qū)域內(nèi)的神經(jīng)活動模式,，海馬區(qū)域與記憶的形成和恢復(fù)有關(guān)。
在老鼠學(xué)習(xí)如何從迷宮中找到出路,，以及處于睡眠狀態(tài)的后學(xué)習(xí)過程中,，Sidney Wiener和同事記錄了來自老鼠大腦內(nèi)側(cè)前額葉皮質(zhì)中的幾組神經(jīng)元活動。當(dāng)老鼠們在迷宮中學(xué)習(xí)如何找出路時,，內(nèi)側(cè)前額葉皮質(zhì)中神經(jīng)元的活動發(fā)生了變化,，而在它們睡覺時，類似的活動重復(fù)出現(xiàn)了,。通常情況下,，這些重復(fù)事件出現(xiàn)的時間與海馬區(qū)域內(nèi)的固化活動同步。（生物谷Bioon.com）
生物谷推薦原始出處：
Nature Neuroscience 12, 919 - 926 (2009)31 May 2009 | doi:10.1038/nn.2337
Replay of rule-learning related neural patterns in the prefrontal cortex during sleep
Adrien Peyrache1, Mehdi Khamassi1,2, Karim Benchenane1, Sidney I Wiener1 & Francesco P Battaglia1,3
Slow-wave sleep (SWS) is important for memory consolidation. During sleep, neural patterns reflecting previously acquired information are replayed. One possible reason for this is that such replay exchanges information between hippocampus and neocortex, supporting consolidation. We recorded neuron ensembles in the rat medial prefrontal cortex (mPFC) to study memory trace reactivation during SWS following learning and execution of cross-modal strategy shifts. In general, reactivation of learning-related patterns occurred in distinct, highly synchronized transient bouts, mostly simultaneous with hippocampal sharp wave/ripple complexes (SPWRs), when hippocampal ensemble reactivation and cortico-hippocampal interaction is enhanced. During sleep following learning of a new rule, mPFC neural patterns that appeared during response selection replayed prominently, coincident with hippocampal SPWRs. This was learning dependent, as the patterns appeared only after rule acquisition. Therefore, learning, or the resulting reliable reward, influenced which patterns were most strongly encoded and successively reactivated in the hippocampal/prefrontal network.
1 Laboratoire de Physiologie de la Perception et de l'Action, Collège de France, Centre National de la Recherche Scientifique, Paris, France.
2 Institut des Systèmes Intelligents et de Robotique, Université Pierre et Marie Curie – Paris 6, Centre National de la Recherche Scientifique, Paris, France.
3 Center for Neuroscience, Swammerdam Institute for Life Sciences, Faculty of Science, Universiteit van Amsterdam, Amsterdam, The Netherlands.
