近期,，英國研究人員表示，他們發(fā)現(xiàn)能夠抑制食欲的自然成份，如果成功發(fā)展成為藥品,，將可以讓人只有在饑餓時才吃東西,，且可以免除一般減肥藥物的副作用。
曼徹斯特大學的專家說,，他們希望能讓人不再只為了享受而進食,，而且發(fā)展出來的藥物，可能也可以用來治療酒癮和毒癮,。生物谷啟用新域名 www.bioon.net
科學家發(fā)現(xiàn)的這種成份稱為hemopressin,，在人體自然存在，會影響享受零食或吸煙時趨于活躍的腦部酬償中樞,。研究顯示,，hemopressin能阻隔腦部的這個區(qū)塊，減少吃東西的滿足感,。
最新的研究刊登在《神經(jīng)科學期刊》,，報告的作者之一托德認為，人體自然形成的hemopressin可以抑制食欲而不致于有副作用,。
實驗顯示,，攝取hemopressin的老鼠食量減少，托德說：“我們現(xiàn)在計劃進一步研究,。我們的發(fā)現(xiàn)顯示安全性沒有問題,，但這不能立刻套用在人類身上。”這項發(fā)現(xiàn)讓科學家進一步了解大腦如何控制食欲,，也為找出影響大腦這個功能和研發(fā)抗肥胖藥物開啟了新的渠道,。(生物谷Bioon.net)
生物谷推薦原文出處：
The Journal of Neuroscience, doi:10.1523/JNEUROSCI.5455-09.2010
The Peptide Hemopressin Acts through CB1 Cannabinoid Receptors to Reduce Food Intake in Rats and Mice
Garron T. Dodd,1 Giacomo Mancini,2 Beat Lutz,2 and Simon M. Luckman1
1Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom, and 2Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Duesbergweg 6, D-55099 Mainz, Germany
Hemopressin is a short, nine amino acid peptide (H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH) isolated from rat brain that behaves as an inverse agonist at the cannabinoid receptor CB1, and is shown here to inhibit agonist-induced receptor internalization in a heterologous cell model. Since this peptide occurs naturally in the rodent brain, we determined its effect on appetite, an established central target of cannabinoid signaling. Hemopressin dose-dependently decreases night-time food intake in normal male rats and mice, as well as in obese ob/ob male mice, when administered centrally or systemically, without causing any obvious adverse side effects. The normal, behavioral satiety sequence is maintained in male mice fasted overnight, though refeeding is attenuated. The anorectic effect is absent in CB1 receptor null mutant male mice, and hemopressin can block CB1 agonist-induced hyperphagia in male rats, providing strong evidence for antagonism of the CB1 receptor in vivo. We speculate that hemopressin may act as an endogenous functional antagonist at CB1 receptors and modulate the activity of appetite pathways in the brain.
