了解記憶增強(qiáng)機(jī)制,，對于拓寬我們關(guān)于記憶過程的知識、對于潛在臨床應(yīng)用都至關(guān)重要,。然而對此我們卻知之甚少?，F(xiàn)在，用大鼠所做實驗表明,，施用“胰島素樣生長因子-II” (IGF-II) （一般與身體組織生長和修復(fù)有關(guān)的蛋白）,，可以顯著增強(qiáng)記憶保持、促進(jìn)被稱為“長時程增強(qiáng)”的記憶指標(biāo)和防止忘記,。IGF-II通過啟動能導(dǎo)致“突觸增強(qiáng)”的信號級聯(lián)網(wǎng)絡(luò)發(fā)揮作用,，在緊接著學(xué)習(xí)之后的短時間內(nèi)最為有效,。因此，IGF-II是調(diào)控認(rèn)知增強(qiáng)的一個潛在目標(biāo),。（生物谷Bioon.com）
生物谷推薦原文出處：
Nature doi:10.1038/nature09667
A critical role for IGF-II in memory consolidation and enhancement
Dillon Y. Chen,Sarah A. Stern,Ana Garcia-Osta,Bernadette Saunier-Rebori,Gabriella Pollonini,Dhananjay Bambah-Mukku,Robert D. Blitzer& Cristina M. Alberini
We report that, in the rat, administering insulin-like growth factor II (IGF-II, also known as IGF2) significantly enhances memory retention and prevents forgetting. Inhibitory avoidance learning leads to an increase in hippocampal expression of IGF-II, which requires the transcription factor CCAAT enhancer binding protein β and is essential for memory consolidation. Furthermore, injections of recombinant IGF-II into the hippocampus after either training or memory retrieval significantly enhance memory retention and prevent forgetting. To be effective, IGF-II needs to be administered within a sensitive period of memory consolidation. IGF-II-dependent memory enhancement requires IGF-II receptors, new protein synthesis, the function of activity-regulated cytoskeletal-associated protein and glycogen-synthase kinase 3 (GSK3). Moreover, it correlates with a significant activation of synaptic GSK3β and increased expression of GluR1 (also known as GRIA1) α-amino-3-hydroxy-5-methyl-4-isoxasolepropionic acid receptor subunits. In hippocampal slices, IGF-II promotes IGF-II receptor-dependent, persistent long-term potentiation after weak synaptic stimulation. Thus, IGF-II may represent a novel target for cognitive enhancement therapies.
