了解記憶增強機制，對于拓寬我們關于記憶過程的知識,、對于潛在臨床應用都至關重要,。然而對此我們卻知之甚少。現在,，用大鼠所做實驗表明,，施用“胰島素樣生長因子-II” (IGF-II) （一般與身體組織生長和修復有關的蛋白），可以顯著增強記憶保持,、促進被稱為“長時程增強”的記憶指標和防止忘記,。IGF-II通過啟動能導致“突觸增強”的信號級聯(lián)網絡發(fā)揮作用，在緊接著學習之后的短時間內最為有效,。因此,，IGF-II是調控認知增強的一個潛在目標。（生物谷Bioon.com）
生物谷推薦原文出處：
Nature doi:10.1038/nature09667
A critical role for IGF-II in memory consolidation and enhancement
Dillon Y. Chen,Sarah A. Stern,Ana Garcia-Osta,Bernadette Saunier-Rebori,Gabriella Pollonini,Dhananjay Bambah-Mukku,Robert D. Blitzer& Cristina M. Alberini
We report that, in the rat, administering insulin-like growth factor II (IGF-II, also known as IGF2) significantly enhances memory retention and prevents forgetting. Inhibitory avoidance learning leads to an increase in hippocampal expression of IGF-II, which requires the transcription factor CCAAT enhancer binding protein β and is essential for memory consolidation. Furthermore, injections of recombinant IGF-II into the hippocampus after either training or memory retrieval significantly enhance memory retention and prevent forgetting. To be effective, IGF-II needs to be administered within a sensitive period of memory consolidation. IGF-II-dependent memory enhancement requires IGF-II receptors, new protein synthesis, the function of activity-regulated cytoskeletal-associated protein and glycogen-synthase kinase 3 (GSK3). Moreover, it correlates with a significant activation of synaptic GSK3β and increased expression of GluR1 (also known as GRIA1) α-amino-3-hydroxy-5-methyl-4-isoxasolepropionic acid receptor subunits. In hippocampal slices, IGF-II promotes IGF-II receptor-dependent, persistent long-term potentiation after weak synaptic stimulation. Thus, IGF-II may represent a novel target for cognitive enhancement therapies.
