生物谷報道：轉(zhuǎn)錄因子Kruppel-like transcription factors （KLF2）長期被認(rèn)為在控制成熟T細(xì)胞的存活和靜止中扮演一個關(guān)鍵角色，因為缺乏KLF2的T細(xì)胞會在胸腺中形成,，但不能進入周圍淋巴器官,。
本周出版的Nature上一項新的研究工作對這種表現(xiàn)型提出了另一種解釋，這種解釋與KLF2作為胸腺細(xì)胞和T細(xì)胞遷移的一個調(diào)控因子這樣一個完全不同的功能是一致的,。 KLF（Krüppel類轉(zhuǎn)錄因子）家族的蛋白參與脊椎動物發(fā)育的很多方面,，并且與若干疾病狀態(tài)有關(guān)。KLF2這一新發(fā)現(xiàn)的功能與不同細(xì)胞類型的終端分異所必需的其他一些KLF是相似的,。同時,，編輯對此文章進行了相關(guān)的評論。
The transcription factor KLF2 has long been thought to play a critical role in controlling survival and quiescence of mature T cells, since KLF2-deficient T cells develop in the thymus but fail to populate peripheral lymph organs. A new study offers an alternative explanation for this phenotype, consistent with an entirely different function for KLF2 as a regulator of thymocyte and T-cell migration. Proteins of the KLF (Krüppel-like transcription factor) family are involved in many aspects of vertebrate development and are implicated in a number of disease states. This newly discovered role for KLF2 is similar to some other KLFs that are essential for terminal differentiation of various cell types.
原始出處：
Letter: Kruppel-like factor 2 regulates thymocyte and T-cell migration
Corey M. Carlson, Bart T. Endrizzi, Jinghai Wu, Xiaojie Ding, Michael A. Weinreich, Elizabeth R. Walsh, Maqsood A. Wani, Jerry B. Lingrel, Kristin A. Hogquist and Stephen C. Jameson
doi:10.1038/nature04882
First paragraph | Full Text | PDF (482K) | Supplementary information
