發(fā)表在最新在線版刊物BMC Veterinary Research上的文章表示,，淋巴結(jié)是傳播少量朊病毒到神經(jīng)系統(tǒng)的關(guān)鍵所在,，這是羊搔癢癥和人類克雅氏癥的病原。
盡管局域性的淋巴結(jié)對于神經(jīng)系統(tǒng)感染大量的朊病毒并沒有明顯作用,，但我們不能排除其它可能：淋巴結(jié)和朊病毒在身體內(nèi)向其它非神經(jīng)組織傳播有關(guān),。
以上研究由德國柏林的Robert-Koch研究所的Michael Beekes小組負(fù)責(zé)進(jìn)行，這為揭開朊病毒是如何從感染區(qū)域轉(zhuǎn)移到大腦和脊髓的機(jī)制帶來了幫助,，在中樞神經(jīng)系統(tǒng)這些病原會造成不可逆轉(zhuǎn)的致命損傷,。
Christine Kratzel和同事研究了淋巴系統(tǒng)在羊搔癢癥轉(zhuǎn)移到大鼠神經(jīng)中的作用－淋巴系統(tǒng)是淋巴結(jié)組成的網(wǎng)絡(luò)，這是我們身體的防御系統(tǒng)的一部分,。小組發(fā)現(xiàn)在發(fā)生大量或中量朊病毒感染后6天內(nèi)摘除感染處附近的淋巴結(jié),，動物依然會患病。而在感染前4周摘除,，則高劑量病原致病而低劑量不會（在研究的整個314天時間內(nèi)）,。結(jié)果顯示在發(fā)生低劑量病原感染時，淋巴系統(tǒng)對于朊病毒向中樞神經(jīng)系統(tǒng)的轉(zhuǎn)移很重要,。
小組同時發(fā)現(xiàn)在移除淋巴結(jié)而且傷口未愈合時,，朊病毒感染會持續(xù)加速。以上發(fā)現(xiàn)非常重要,，因?yàn)榭茖W(xué)家對于淋巴系統(tǒng)和炎癥反應(yīng)在朊病毒感染在身體內(nèi)的傳播過程中的作用了解很少,。而清楚了解病原傳播的過程中各個因素能幫助科學(xué)家和醫(yī)生發(fā)明新的預(yù)防和治療朊病毒疾病的方法,。（教育部科技發(fā)展中心）
原文鏈接：http://www.physorg.com/news109905897.html
原始出處:
Relevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters
Christine Kratzel , Dominique Kruger and Michael Beekes
BMC Veterinary Research 2007, 3:22doi:10.1186/1746-6148-3-22
Published:25 September 2007
Abstract (provisional)
Background
The exact role of the lymphoreticular system in the spread of peripheral prion infections to the central nervous system still needs further elucidation. Against this background, the influence of the regional lymph node (Ln. popliteus) on the pathogenesis of scrapie was monitored in a hamster model of prion infection via the footpad.
Methods
Surgical lymphadenectomy was carried out at different time points after infection, or prior to inoculation, in order to elucidate the impact of the lymph node on lethal neuroinvasion.
Results
The Ln. popliteus did not show an influence on pathogenesis when a high dose of infectivity was administered. However, it was found to modulate the interval of time until the development of terminal scrapie in a subset of animals lymphadenectomized after low-dose infection. In additon, lymphadenectomy performed four weeks before inoculation prevented cerebral PrPTSE deposition and development of disease during the period of observation (314 days) in the majority of hamsters challenged with a very low dose of scrapie agent.
Conclusions
Our findings suggest the regional lymph node as a potentially facilitating or even essential factor for invasion of the brain after peripheral challenge with low doses of infectious scrapie agent. The invasive in vivo approach pursued in this study may be applied also to other animal species for further elucidating the involvement of lymphoid tissue in the pathogenesis of experimental and natural TSEs.
