比利時研究人員發(fā)現(xiàn),，益生菌等一些腸道細菌能影響人們的食欲和新陳代謝,。人們今后可以通過定期服食特定食品或食品添加劑,，通過調(diào)節(jié)腸道內(nèi)的細菌種類和數(shù)量,，達到控制體重的目的,。
魯汶天主教大學的研究人員通過多年的研究發(fā)現(xiàn),，某些腸道細菌在腸道里控制著內(nèi)大麻醇的產(chǎn)生,，而內(nèi)大麻醇可以影響?zhàn)囸I感和脂肪細胞里脂肪的堆積程度。
研究人員將實驗鼠分為兩組：一組食物里加入益生菌,，另一組則不添加作為對照組,。喂養(yǎng)一段時間后，研究人員對兩組實驗鼠的有關(guān)肥胖指標進行分析發(fā)現(xiàn),，益生菌影響實驗鼠的內(nèi)大麻醇系統(tǒng),。也就是說，喂食益生菌的實驗鼠身體比較“苗條”,。
研究人員表示,，如果這項實驗在人身上得到驗證，那么體重超標的人今后只要服用添加腸道細菌的特定食品或食品添加劑,，就能達到減肥的目的,。（生物谷Bioon.com）
生物谷推薦原文出處：
Molecular Systems Biology doi:10.1038/msb.2010.46
The endocannabinoid system links gut microbiota to adipogenesis
Giulio G Muccioli1,2, Damien Naslain1,3, Fredrik B?ckhed4, Christopher S Reigstad4, Didier M Lambert1,5, Nathalie M Delzenne1,3 & Patrice D Cani1,3
1Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium
2Bioanalysis and Pharmacology of Bioactive Lipids laboratory, Brussels, Belgium
3Metabolism and Nutrition research group, Brussels, Belgium
4Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden
5Medicinal Chemistry, Brussels, Belgium
Obesity is characterised by altered gut microbiota, low-grade inflammation and increased endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota and eCB signalling has yet to be confirmed. Here, we report that gut microbiota modulate the intestinal eCB system tone, which in turn regulates gut permeability and plasma lipopolysaccharide (LPS) levels. The impact of the increased plasma LPS levels and eCB system tone found in obesity on adipose tissue metabolism (e.g. differentiation and lipogenesis) remains unknown. By interfering with the eCB system using CB1 agonist and antagonist in lean and obese mouse models, we found that the eCB system controls gut permeability and adipogenesis. We also show that LPS acts as a master switch to control adipose tissue metabolism both in vivo and ex vivo by blocking cannabinoid-driven adipogenesis. These data indicate that gut microbiota determine adipose tissue physiology through LPS-eCB system regulatory loops and may have critical functions in adipose tissue plasticity during obesity.
