2010年2月18日,，北京生命科學研究所周儉民實驗室在Cell Host & Microbe雜志在線發(fā)表文章報道了 (Pseudomonas syringae)效應蛋白AvrB干擾植物激素信號途徑的分子機理。
效應蛋白AvrB可以誘導激素茉莉酸(Jasmonic acid)信號途徑的基因表達,，增加植物對丁香假單胞菌的感病性,。該工作發(fā)現(xiàn)，在擬南芥中AvrB的這些功能依賴于MAP kinase 4 (MPK4),、HSP90分子伴侶復合體以及AvrB互作蛋白RIN4,。AvrB與HSP90蛋白復合體、MPK4互作,，誘導了MPK4的磷素化,。RIN4可能作用與MPK4的下游，是茉莉酸信號途徑的一個正調控因子,。這些發(fā)現(xiàn)揭示了AvrB干擾植物激素,，促進植物感病的一個新的信號通路。（生物谷Bioon.com）
生物谷推薦原始出處：
Cell Host & Microbe, Volume 7, Issue 2, 164-175, 18 February 2010 DOI:10.1016/j.chom.2010.01.009
Pseudomonas syringae Effector Protein AvrB Perturbs Arabidopsis Hormone Signaling by Activating MAP Kinase 4
Haitao Cui, Yujing Wang, Li Xue, Jinfang Chu, Cunyu Yan, Jihong Fu, Mingsheng Chen, Roger W. Innes, Jian-Min Zhou
Pathogenic microbes often modulate phytohormone physiology in the host to their advantage. We previously showed that the Pseudomonas syringae effector protein AvrB perturbs hormone signaling, as exemplified by upregulated expression of jasmonic acid response genes, and enhances plant susceptibility. Here we show that these effects of AvrB require the Arabidopsis mitogen-activated protein kinase MAP kinase 4 (MPK4), HSP90 chaperone components, and the AvrB-interacting protein, RIN4. AvrB interacts with MPK4 and the HSP90 chaperone, and AvrB induces MPK4 activation in a manner promoted by HSP90; RIN4 likely acts downstream of MPK4. These findings link Arabidopsis proteins MPK4, HSP90, and RIN4 into a pathway that P. syringae AvrB activates for the benefit of the bacterium, perturbing hormone signaling and enhancing plant susceptibility.
